(2004, NS 130)
Gunnar Bjursell, Astrid Gräslund, Anders Liljas, Lars Thelander
September 10-15
Tällberg, Dalarna, Sweden
Proceedings: Molecular Mechanisms of Biological Systems, Special issue of FEBs
Letters, 2005, vol. 579, no. 4, Elsevier, Amsterdam.
There is a dramatic expansion in our knowledge about the complexity of the biological systems and the processes that take place in living cells. Despite the wealth of knowledge we can describe some of the processes in increasing detail, but the understanding is often lagging behind. We find it important to bring together scientists of different fields of biology and physical and theoretical chemistry as an attempt to catalyze the development for a deeper understanding of biological phenomena. We have focused on some of the basic biological phenomena, where there is tremendous research activities but where the knowledge generally is at a descriptive level.
The main aims of the symposium is to:
1. Bring scientists from a number of neighboring biological fields together
for exchange of approaches and results.
2. Strengthen the contacts between biological experimentalists with physical
chemists and theoretical chemists.
3. Stimulate Swedish participation in these activities.
| Sept. 10 | Arrival |
| 18:00 | Dinner |
| 19:30 | Anders Liljas, "Welcome to our symposium in Dalarna" |
| Opening session (Chair: Bengt Nordén) | |
| 19:35 | Aaron Klug, "A memoir of Francis Crick" |
| 20:15 | Harry Noller, "Ribosomal Explorations" |
| Sept. 11 | DNA polymerases and DNA repair (Chair: L. Thelander and Gunnar Bjursell) |
| 09:00 | Elisabeth Blackburn, "Telomeres, telomerase and their cellular growth effects" |
| 09:45 | Thomas Cech, "Structure of the human protection of telomeres complex: implications for telomerase regulation" |
| 10:30 | Coffee |
| 11:00 | John Kuriyan, "Sliding clamps and DNA polymerase clamp loaders" |
| 11:45 | Tom Steitz, "Molecular mechanisms of initiation, elongation, translocation and strand separation by polynucleotide polymerases" |
| 12:30 | Lunch |
| 14:00 | Wei Yang, "Portraits of a Y-family polymerase: error-prone
and lesion-bypass synthesis" |
| 14:45 | Alan Lehmann, "Replication of damaged DNA in human cells" |
| 15:30 | Coffee |
| 16:00 | Bruce Stillman, "Duplicating the genomes of eukaryotes" |
| 16:45 | Natalie Ahn, "Proteomics and signal transduction" |
| 17:30 | Session closed |
| 18:00 | Bus to Leksand |
| 18:30 | Swedish organ musik in Leksand's church. Henrik Alinder. Buffet dinner in Leksand's art museum. Presentation by the director. |
| 21:00 | Return to Åkerblad's by bus |
| Sept. 12 | Chromatin structure and transcription (Chair: A. Klug) |
| 09:00 | Aaron Klug A. Recent biomedical insights of gene regulation by zinc fingers B. Introduction to chromatin |
| 09:30 | Karolin Luger, "Chromatin structure and dynamics" |
| 10:15 | Coffee |
| 10:45 | Roger Kornberg, "RNA polymerase II transcription: structure and regulation" |
| 11:30 | Joan Conaway, "RNA polymerase II transcriptional regulatory mechanisms" |
| 12:15 | Robert G. Roeder, "Integrated functions of diverse transcriptional coactivators on recombinant chromatin templates" |
| 13:00 | Lunch |
| Transport (Chair: G. von Heijne) | |
| 14:00 | Günther Blobel, "Traffic into the nucleus" |
| 14:45 | Arthur E. Johnson, "Nascent chain folding regulates ribosomal interactions at the ER membrane" |
| 15:30 | Coffee |
| 16:00 | Peter Walter, "Mechanism of SRP-dependent protein targeting" |
| 16:45 | Stephen Cusack, "Structure of the /Alu/ domain from an archaebacterial signal recognition particle" |
| 17:30 | Roland Beckmann, "A structural view of cotranslational protein targeting" |
| Imaging (Chair: S. Forsén) | |
| 20:00 | Roger Y. Tsien, "Building molecules to spy on cells and tumors" |
| 20:45 | Wolfgang Baumeister, "Exploring the inner space of cells by cryoelectron tomography" |
| Sept. 13 | Translation (Chair: A. Liljas and A. Gräslund) |
| 09:00 | Stephen Cusack, "Error correction by aminoacyl-tRNA synthetases: leucyl-tRNA synthetase and prolyl-tRNA synthetase" |
| 09:45 | Marina Rodnina, "Substrate selection and catalysis by the ribosome" |
| 10:30 | Coffee |
| 11:00 | Carol Robinson, "A mass spectrometry investigation of the complexes involved in translation" |
| 11:45 | Ada Yonath, "The spectacular ribosomal architecture: positional
catalysis, tunnel mobility and antibiotics synergism" |
| 12:30 | Lunch |
| 14:00 | Venki Ramakrishnan, "Mechanistic insights into decoding of mRNA from crystal structures of the 30S subunit" |
| 14:45 | Tom Steitz, "Structural insights into the peptidyl-transferase
reaction and antibiotic resistance in the 50S subunit" |
| 15:30 | Coffee |
| 16:00 | Måns Ehrenberg, "Ribosomal GTP games" |
| 16:45 | Joachim Frank, "The process of decoding and accommodation -- insights from cryo-EM snapshots" |
| 19:00 | Conference dinner. Folk music entertainment. |
| Sept. 14 | Departure or excursion |
| Two alternatives: | |
| 1. The home and the museum of the painter Anders Zorn (1860-1920), Mora | |
| 2. Karin and Carl Larsson, Sundborn | |
| Sept. 15 | Late departure |
We are currently working on the web site. Please report errors or problems.
