Towards an Understanding of Integrative Brain Functions
Intrinsic function of a neuronal network - a vertebrate central pattern generator
Sten Grillnera,*, Örjan
Ekebergb, Abdeljabbar El Maniraa, Anders
Lansnerb, David Parkera, Jesper
Tegné a, b, Peter Walléna
aNobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden, bDepartment of Numerical Analysis and Computing Science, Royal Institute of Technology, S-100 44 Stockholm, Sweden
The cellular bases of vertebrate locomotor behaviour is reviewed using the lamprey as a model system. Forebrain and brainstem cell populations initiate locomotor activity via reticulospinal fibers activating a spinal network comprised of glutamatergic and glycinergic interneurons. The role of different subtypes of Ca2+ channels, Ca2+ dependent K+ channels and voltage dependent NMDA channels at the neuronal and network level is in focus as well as the effects of different metabotropic, aminergic and peptidergic modulators that target these ion channels. This is one of the few vertebrate networks that is understood at a cellular level.
*Corresponding author: Sten.Grillner@neuro.ki.se
Brain Research Reviews 26 (1998)
Copyright © 1998 Elsevier Science B. V. All rights reserved.
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