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Estrogens and Women's Health - Benefit or Threat?

(1999, NS 113)
June 29-July 1, 1999
Bofors Hotel, Karlskoga, Sweden
Organizers: Professors Jan-Åke Gustafsson and Jan Carlstedt-Duke, Karolinska Institutet

Attending the symposium were 46 people, including 26 lecturers. Invited lecturers included the foremost researchers in this field from Europe and the United States (among them Bert O'Malley, Donald Pfaff, Evan Simpson, Kathryn Horwitz, Benita Katzenellenbogen and Craig Jordan).

The symposium discussed estrogens and women's health, currently one of the most intensively discussed medical problems, both nationally and internationally and among physicians as well as the general public. It focused in particular on issues related to post-menopausal hormone replacement therapy and associated elevated risk of breast and uterine cancer. Many other crucial estrogen-related themes were discussed as well. They included the role of so-called xenoestrogens (chemicals that contaminate nature and that have an estrogenic effect) in the supposed decline in sperm counts and the rising incidence of testicular cancer among Western men, the role of phytoestrogens (plant estrogens that we ingest via food) in protecting against breast cancer, and the effectiveness of estrogenic drugs against fragile bones, cardiovascular diseases, Alzheimer's disease, etc.

Female sex hormones have widespread clinical use for a variety of indications, and there is a continuous debate concerning possible harmful effects due to such treatment. The symposium discussed the key importance of developing more selective drugs with agonistic or antagonistic estrogenic effects. In recent years, new knowledge has greatly changed our view of the effects of estrogen. Various new data were presented at the meeting. For example, persuasive evidence was presented for the view that the new estrogen receptor ERbeta has a biological function different from that of ERalpha. ERbeta thus seems to have an anti proliferative effect both in the prostate and the uterus; if these findings can be confirmed, they may open up interesting new possibilities for the treatment of prostate and uterine cancer.

The symposium volume was published in the Journal of Steroid Biochemistry and Molecular Biology during 2000.

Program  
June 29 - Tuesday Bofors Hotel
8.00 a.m.-8.40 a.m. The estrogen receptor family and its ligands
Chairmen: Elwood Jensen, Håkan Eriksson

Kathryn Horwitz, University of Colorado Health Science Center, Denver: "Growth regulation and steroid hormone resistance in breast cancer"
8.40 a.m.-9.20 a.m. Jan-Åke Gustaffson, Karolinska Institutet, Stockholm: "ERB-a new paradigm in estrogen mechanism of action"
9.20 a.m.-10.00 a.m. Roderick Hubard, University of York, York: "Structural aspects of agonism and antagonism in the estrogen receptor"
10.30 am-11.10 am Donald McDonnell, Duke University Medical Center: "Mechanistic distinctions among the selective estrogen receptor modulators"
11.10 am-11.50 pm

Benita Katzenellenbogen, University of Illinois: "Molecular mechanisms of estrogen action: Selective ligands and receptor pharmacology"

13.30 pm - 14.10 pm Kenneth Korach, National Institute of Environmental Health Sciences, Research Triangle Park: "Estrogen receptor knock-out mice: Molecular and endocrine phenotypes"
14.10 pm - 14.50 pm Kennet Setchell, Univreisty of Cincinnati Medical Center, Cincinnati
15.20 pm - 16.00 pm Peter Kushner, University of California, San Francisco: "Tamoxifen behavior and misbehavior"
June 30 - Wednesday Björkborn Manor
  The physiology and pathology of estrogen action

Chairmen: Etienne-Emile Baulieu, Thomas Perlmann
8.00 am - 8.40 am Bert O'Malley, Baylor College of Medicine, Houston: "Role of steroid receptor co-activators in transcriptional regulation"
8.40 am - 9.20 am Gordon Hager, National Cancer Institute, Bethesda: "Subcellular trafficking and intranuclear targeting of steroid receptors in living cells"
9.20 - 10.00 am Adriana Maggi, University of Milan, Milan: "Estrogen effect on neural cell functions"
10.30 am - 11.10 am Martin Ritzén, Karolinska Institutet, Stockholm: "Estrogens and human growth"
11.10 am - 11.50 am Donald Pfaff, Rockefeller University, New York: "Effects of estrogens on brain and behavior"
13.30 pm - 14.10 pm Michael Mendelsohn, Tufts University School of Medicine, Boston: "Mechanisms of estrogen action in the cardiovascular system"
July 1 - Thursday Bofors Hotel
  Benefits and risks of estrogens

Chairmen: Luciano Martini, Britt-Marie Landgren
8.40 am - 9.20 am Lewis Kuller, University of Pittsburgh School of Public Health, Pittsburgh: "Estrogens and women's health"
9.20 am - 10.00 am John Stevenson, Imperial College School of Medicine, London: "Cardiovascular effects of estrogens"
10.30 am - 11.10 am Ingemar Persson, Karolinska Institutet, Stockholm: "Estrogens in the causation of breast, endometrial and ovarian cancers. Evidence and hypotheses from epidemiological findings"
11.10 am - 11.50 am Jonathan Reeve, Cambridge University School of Public Health, Cambridge: "How do women develop fragile bones?"
13.30 am - 14.10 pm Håkan Olsson, University of Lund, Lund: "Tumour biology of a breast cancer at least partly reflect the biology of the tissue/epithelial cell of origin at the time of initiation - a hypothesis"
14.10 pm - 14.50 pm Craig Jordan, Northwestern University Medical School, Chicago: "Tamoxifen, raloxifene and the prevention of breast cancer"
Participants  
Dr. Monica Ahlberg
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Lena Magnell
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Tova Almlöf
Karolinska Insititutet
NOVUM, Huddinge, Sweden
Dr. Sari Mäkelä
Karolinska Institutet
Huddinge, Sweden
Dr. Göran Andersson
Karolinska Institutet
Huddinge Hospital
Huddinge, Sweden
Dr. Luciano Martini
Univ. Degli Studi Milan
Milan, Italy
Dr. Etienne-Emile Baulieu
Ints. National de la Santé et
de Collège de France
INSERM U488, France
Dr. Donald P. McDonnell
Duke University Medical Center, USA
Dr. Thomas Bergman
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Michael E. Mendelsohn
New England Medical Center, USA
Dr. Jan Carlstedt-Duke
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Stefan Nilsson
NOVUM, Huddinge
Sweden
Dr. Hans Carlsten
University of Göteborg
Göteborg, Sweden
Dr. Bert O'Malley
Baylor College of Medicine
USA
Dr. Eva Enmark
Karolinska Institutet
Huddinge, Sweden
Dr. Claes Ohlsson
Göteborg University
Göteborg, Sweden
Dr. Håkan Eriksson
Karolinska Institutet
Karolinska Hospital
Stockholm, Sweden
Dr. Håkan Olsson
Universitetssjukjuset
Lund, Sweden
Dr. Jan-Åke Gustafsson
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Thomas Perlmann
Karolinska Institutet
Stockholm, Sweden
Dr. Kerstin Hagenfeldt
Karolinska Institutet
Stockholm, Sweden
Dr. Ingemar Persson
Karolinska Institutet
Stockholmm, Swedem
Dr. Gordon Hager
National Cancer Institute
Bethesda, USA
Dr. Donald W. Pfaff
The Rockefeller University USA
Dr. Kathryn B. Horwitz
University of Colorado
Denver, USA
Dr. Jonathan Reeve
Cambridge University
Cambridge, UK
Dr. Rod E. Hubbard
University of York
U K
Dr. Martin Ritzén
Karolinska Hospital
Stockholm, Sweden
Dr. Elwood Jensen
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Shigehira Saji
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Lotta Johansson
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Risto Santi
University of Turku
Turku, Finland
Dr. Craig Jordan
Northwestern University Medical School
Chicago, USA
Dr. Kenneth Setchell
Children's Hospital & Medical Center, Cincinnati, USA
Dr. Benita S. Katzenellenbogen
University of Illinois
Urbana, USA
Dr. Maria Sjöberg
Karolinska Institutet
Stockholm, Sweden
Dr. Kenneth Korach
NIH-NIEHS
USA
Dr. Olle Söder
Karolinska Institutet
Astrid Lindgren Children's Hospital, Stockholm, Sweden
Dr. Lewis H. Kuller
University of Pittsburg
Pittsburg, USA
Dr. John C. Stevenson
Imperial College of Science, Technology, London, UK
Dr. Peter Kushner
University of California
San Francisco, USA
Dr. Anders Ström
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Britt-Marie Landgren
Karolinska Institutet
Huddinge, Sweden
Dr. Eckardt Treuter
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Jörg Leers
Karolinska Institutet
Huddinge, Sweden
Dr. Michel Tujague
Karolinska Institutet
NOVUM, Huddinge, Sweden
Dr. Adriana Maggi
University of Milan
Milan, Italy
Dr. Margret Warner
Karolinska Institutet
NOVUM, Huddinge, Sweden

 

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