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Septicemia and Shock: Pathogenesis and Novel Therapeutic Strategies

(2003, NS 124)
Anna Norrby-Teglund, Staffan Normark, Ragnar Norrby, Malak Kotb, Thierry Calandra, Terje Espevik
May 15-17
Nobel Forum, Karolinska Institutet, Stockholm, Sweden
Proceedings: Scandinavian Journal of Infectious Diseases, 2003, vol. 35, no. 9, Stockholm.

The incidence of sepsis is increasing and sepsis and its complications remain a challenging problem to basic scientists and clinicians. Septic shock is a leading cause of death in critical care units world-wide despite improvements of the supportive care available to treat septic patients. The disease expression is highly varying, and the severity of infection is influenced by numerous factors including among others the nature of infection, host genetics, and optimal time for clinical intervention. Significant advances in the understanding of the complex biological processes responsible for the clinical syndrome have recently been made and resulted in the identification of many promising new therapeutic targets, including bacterial toxins, host-derived mediators, and downstream processes such as coagulation and the endocrine response.

The goal of this meeting was to bring together researchers and clinicians with unique expertise within the various areas of sepsis to provide novel insight and identify future tasks that remain to be adressed in the sepsis field. The symposium took place in May 15-17, 2003 at the Nobel Forum at the Karolinska Institutet. The meeting covered the whole spectrum from molecular pathogenesis to the threat of antibiotic resistance and the use of immunotherapy for the treatment of sepsis. The original papers were published in the fall of 2003 in Scandinavian Journal of Infectious Diseases.

Invited Speakers
Professor Shizuo Akira, Japan
Professor Jan Andersson, Sweden
Professor Ulf Andersson, Sweden
Professor Alfred Ayala, USA
Professor Bruce Beutler, USA
Professor Lars Björck, Sweden
Professor emeritus Hans G. Boman, Sweden
Associate Professor Thierry Calandra, Switzerland
Dr. Sc. Jean-Marc Cavaillon, France
Professor Jonathan Cohen, UK
Professor Terje Espevik, Norway
Assistant Professor Scott Gray-Owen, Canada
Associate Professor Richard S. Hotchkiss, USA
Professor Ann-Beth Jonsson, Sweden
Professor Masao Kimoto, Japan
Professor Malak Kotb, USA
Chief Scientific Officer Arthur Krieg, USA
Professor Michael Levin, USA
Professor Donald Low, Canada
Professor Kouji Matsushima, Japan
Professor Philippe Moreillon, Switzerland
Assistant Professor Victor Nizet, USA
Professor Staffan Normark, Sweden
Associate Professor Anna Norrby-Teglund, Sweden
Professor Ragnar Norrby, Sweden
Professor Steven Opal, USA
Professor Jan Palmblad, Sweden
Associate Professor Sven Pettersson, Sweden
Associate Professor Agneta Richter-Dahlfors, Sweden
Associate Professor Frank Stuber, Germany
Professor Andrej Tarkowski, Sweden
M.D. Elaine Toumanen, USA
Professor Kevin Tracey, USA
Associate Professor John Turnidge, Australia
Dr. Jos A.G. van Strijp, The Netherlands
Professor, Chairman Peter Ward, USA
Associate Professor Eddie Weitzberg, Sweden
Professor Hans Wigzell, Sweden

 

Program  
Thursday, May 15
8:30 a.m. Opening: Hans Wigzell, Sweden
8:45 a.m General Aspects
Chairman: Thierry Calandra, Switzerland

Defining the Problem
Donald E. Low, Canada

Cytokine Cascade in Sepsis
Jean-Marc Cavaillon, France

Severe Sepsis and Septic Shock: Defining the Clinical Problem
Steven M. Opal, USA
10:15 a.m. Coffee
10:45 a.m. Innate Immunity
Chairman: Sven Pettersson, Sweden

Lps2 and Signal Transduction Sepsis: At the Intersetion of Host Responses to Bacteria and Viruses
Bruce Beutler, USA

Tool-like Receptors and their Signaling Mechanisms
Shizou Akira, Japan

The Role of TLR4/MD2 and RP105/MD-1 in Innate Recognition of LPS
Masao Kimoto, Japan
12:15 p.m. Lunch
13:45 p.m. Macrophage Migration Inhibitory Factor (MIF) and Host Innate Immune Responses to Microbes
Thierry Calandra, Switzerland

HMGB-1 in Sepsis
Ulf Andersson, Sweden
14:45 p.m. Coffee
15:15 p.m. Immunosupression in Sepsis
Chairman: Terje Espevik, Norway

Role of Apoptotic Cell Death in Sepsis
Richard S. Hotchkiss, USA

Fas-ligand Mediated Apoptosis in Sepsis and Shock
Alfred Ayala, USA

Anti-Complement Strategies in Experimental Sepsis
Peter A. Ward, USA
18:00 p.m. Reception at the City Hall
   
Friday, May 16
8:30 a.m. The Endothelium and Sepsis
Chairman: Jan Palmblad, Sweden

Endothelin-NO as Regulator of Vascular Tone
Eddie Weitzberg, Sweden

Impairment of and Endothelium-based Anti-coagulation Pathway in Meningococcal Sepsis
Michael Levin, UK
9:30 a.m. Coffee
10:00 a.m. Microbial Virulence Factors
Chairmen: Staffan Normark, Sweden
Malak Kotb, USA


Contact Activation by Pathogenic Bacteria - A Virulence Mechanism Contributing to the Pathophysiology of Sepsis
Lars Björck, Sweden

Bacterial Recognition and Induction of Host Cell Receptors
Ann-Beth Jonsson, Sweden

Neisserial Suppression of Immune Cell Function via Opa-dependent Ligation of the CEACAMI (CD66a) Co-inhibitor Receptor
Scott Gray-Owen, Canada

LPS-inducible Gene Expression Profile in Human Monocytes
Kouji Matshushima, Japan
12:00 noon Lunch
13:30 p.m. Bacterial Protein Toxins and Inflammation
Agneta Richter-Dahlfors, Sweden

Pro-inflammatory Gram-positive Cell Wall Fragments
Philippe Moreillon, Switzerland

Microbial Superantigens: Their Role as Virulence Factors and Ways to Counteract their Action
Andrej Tarkowski, Sweden

Organ Specific Models of Streptococcus Pneumoniae Disease
Elaine Tuomanen, USA
15:30 p.m. Coffee
16:00 p.m. CHIPS, a Bacterial Chemokine Receptor Modulator
Jos van Strijp, The Netherlands

CpG DNA: Trigger of Spesis, or Mediator of Protection, or Both?
Arthur M. Krieg, USA

Cell Distributions and Functions of Toll-like Receptors Studied by Fluorescent Gene Constructs
Terje Espevik, Norway
19:00 p.m. Dinner
   
Saturday, May 17
8:30 a.m. Genetic Susceptibility
Chairman: Jan Andersson, Sweden

Mutagenesis and Genes and Sepsis
Frank Stuber, Germany

Cytokine Polymorphism and Sepsis
Frank Stuber, Germany

HLA Association With Outcomes of Infectious Diseases: The Streptococcal Experience
Malak Kotb, USA
10:00 a.m. Coffee
10:30 a.m. Cathelicidins and Innate Defense against Invasive Bacterial Infection
Victor Nizet, USA

Antibacterial Peptides: From Worms to Human
Hans G. Boman, Sweden
11:30 Lunch
13:00 p.m. Novel Therapeutic Strategies
Chairman: Ragnar Norrby, Sweden

Impact of Antibiotic Resistance on Treatment of Sepsis
John Turnidge, Australia

Vagus Nerve Regulation of Systemic Inflammation
Kevin Tracey, USA

Intravenous Immuneglobulin Therapy in Sepsis with Special Emphasis on Severe Invasive Group A Streptococcal Infections
Anna Norrby-Teglund, Sweden

Recent Developments in the Identification of Novel Therapeutic Targets for the Treatment of Patients with Sepsis and Septic Shock
Jonathan Cohen, UK
15:00 p.m. Farewell snacks

 

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