(2003, NS 124)
Anna Norrby-Teglund, Staffan Normark, Ragnar Norrby, Malak Kotb, Thierry Calandra,
Terje Espevik
May 15-17
Nobel Forum, Karolinska Institutet, Stockholm, Sweden
Proceedings: Scandinavian Journal of Infectious Diseases, 2003, vol. 35,
no. 9, Stockholm.
The incidence of sepsis is increasing and sepsis and its complications remain a challenging problem to basic scientists and clinicians. Septic shock is a leading cause of death in critical care units world-wide despite improvements of the supportive care available to treat septic patients. The disease expression is highly varying, and the severity of infection is influenced by numerous factors including among others the nature of infection, host genetics, and optimal time for clinical intervention. Significant advances in the understanding of the complex biological processes responsible for the clinical syndrome have recently been made and resulted in the identification of many promising new therapeutic targets, including bacterial toxins, host-derived mediators, and downstream processes such as coagulation and the endocrine response.
The goal of this meeting was to bring together researchers and clinicians with unique expertise within the various areas of sepsis to provide novel insight and identify future tasks that remain to be adressed in the sepsis field. The symposium took place in May 15-17, 2003 at the Nobel Forum at the Karolinska Institutet. The meeting covered the whole spectrum from molecular pathogenesis to the threat of antibiotic resistance and the use of immunotherapy for the treatment of sepsis. The original papers were published in the fall of 2003 in Scandinavian Journal of Infectious Diseases.
Invited Speakers
Professor Shizuo Akira, Japan
Professor Jan Andersson, Sweden
Professor Ulf Andersson, Sweden
Professor Alfred Ayala, USA
Professor Bruce Beutler, USA
Professor Lars Björck, Sweden
Professor emeritus Hans G. Boman, Sweden
Associate Professor Thierry Calandra, Switzerland
Dr. Sc. Jean-Marc Cavaillon, France
Professor Jonathan Cohen, UK
Professor Terje Espevik, Norway
Assistant Professor Scott Gray-Owen, Canada
Associate Professor Richard S. Hotchkiss, USA
Professor Ann-Beth Jonsson, Sweden
Professor Masao Kimoto, Japan
Professor Malak Kotb, USA
Chief Scientific Officer Arthur Krieg, USA
Professor Michael Levin, USA
Professor Donald Low, Canada
Professor Kouji Matsushima, Japan
Professor Philippe Moreillon, Switzerland
Assistant Professor Victor Nizet, USA
Professor Staffan Normark, Sweden
Associate Professor Anna Norrby-Teglund, Sweden
Professor Ragnar Norrby, Sweden
Professor Steven Opal, USA
Professor Jan Palmblad, Sweden
Associate Professor Sven Pettersson, Sweden
Associate Professor Agneta Richter-Dahlfors, Sweden
Associate Professor Frank Stuber, Germany
Professor Andrej Tarkowski, Sweden
M.D. Elaine Toumanen, USA
Professor Kevin Tracey, USA
Associate Professor John Turnidge, Australia
Dr. Jos A.G. van Strijp, The Netherlands
Professor, Chairman Peter Ward, USA
Associate Professor Eddie Weitzberg, Sweden
Professor Hans Wigzell, Sweden
| Program | |
| Thursday, May 15 | |
| 8:30 a.m. | Opening: Hans Wigzell, Sweden |
| 8:45 a.m | General Aspects Chairman: Thierry Calandra, Switzerland Defining the Problem Donald E. Low, Canada Cytokine Cascade in Sepsis Jean-Marc Cavaillon, France Severe Sepsis and Septic Shock: Defining the Clinical Problem Steven M. Opal, USA |
| 10:15 a.m. | Coffee |
| 10:45 a.m. | Innate Immunity Chairman: Sven Pettersson, Sweden Lps2 and Signal Transduction Sepsis: At the Intersetion of Host Responses to Bacteria and Viruses Bruce Beutler, USA Tool-like Receptors and their Signaling Mechanisms Shizou Akira, Japan The Role of TLR4/MD2 and RP105/MD-1 in Innate Recognition of LPS Masao Kimoto, Japan |
| 12:15 p.m. | Lunch |
| 13:45 p.m. | Macrophage
Migration Inhibitory Factor (MIF) and Host Innate Immune
Responses to Microbes Thierry Calandra, Switzerland HMGB-1 in Sepsis Ulf Andersson, Sweden |
| 14:45 p.m. | Coffee |
| 15:15 p.m. | Immunosupression in Sepsis Chairman: Terje Espevik, Norway Role of Apoptotic Cell Death in Sepsis Richard S. Hotchkiss, USA Fas-ligand Mediated Apoptosis in Sepsis and Shock Alfred Ayala, USA Anti-Complement Strategies in Experimental Sepsis Peter A. Ward, USA |
| 18:00 p.m. | Reception at the City Hall |
| Friday, May 16 | |
| 8:30 a.m. | The Endothelium and Sepsis Chairman: Jan Palmblad, Sweden Endothelin-NO as Regulator of Vascular Tone Eddie Weitzberg, Sweden Impairment of and Endothelium-based Anti-coagulation Pathway in Meningococcal Sepsis Michael Levin, UK |
| 9:30 a.m. | Coffee |
| 10:00 a.m. | Microbial Virulence Factors Chairmen: Staffan Normark, Sweden Malak Kotb, USA Contact Activation by Pathogenic Bacteria - A Virulence Mechanism Contributing to the Pathophysiology of Sepsis Lars Björck, Sweden Bacterial Recognition and Induction of Host Cell Receptors Ann-Beth Jonsson, Sweden Neisserial Suppression of Immune Cell Function via Opa-dependent Ligation of the CEACAMI (CD66a) Co-inhibitor Receptor Scott Gray-Owen, Canada LPS-inducible Gene Expression Profile in Human Monocytes Kouji Matshushima, Japan |
| 12:00 noon | Lunch |
| 13:30 p.m. | Bacterial Protein Toxins and
Inflammation Agneta Richter-Dahlfors, Sweden Pro-inflammatory Gram-positive Cell Wall Fragments Philippe Moreillon, Switzerland Microbial Superantigens: Their Role as Virulence Factors and Ways to Counteract their Action Andrej Tarkowski, Sweden Organ Specific Models of Streptococcus Pneumoniae Disease Elaine Tuomanen, USA |
| 15:30 p.m. | Coffee |
| 16:00 p.m. | CHIPS, a Bacterial Chemokine Receptor
Modulator Jos van Strijp, The Netherlands CpG DNA: Trigger of Spesis, or Mediator of Protection, or Both? Arthur M. Krieg, USA Cell Distributions and Functions of Toll-like Receptors Studied by Fluorescent Gene Constructs Terje Espevik, Norway |
| 19:00 p.m. | Dinner |
| Saturday, May 17 | |
| 8:30 a.m. | Genetic Susceptibility Chairman: Jan Andersson, Sweden Mutagenesis and Genes and Sepsis Frank Stuber, Germany Cytokine Polymorphism and Sepsis Frank Stuber, Germany HLA Association With Outcomes of Infectious Diseases: The Streptococcal Experience Malak Kotb, USA |
| 10:00 a.m. | Coffee |
| 10:30 a.m. | Cathelicidins
and Innate Defense against Invasive Bacterial
Infection Victor Nizet, USA Antibacterial Peptides: From Worms to Human Hans G. Boman, Sweden |
| 11:30 | Lunch |
| 13:00 p.m. | Novel Therapeutic Strategies Chairman: Ragnar Norrby, Sweden Impact of Antibiotic Resistance on Treatment of Sepsis John Turnidge, Australia Vagus Nerve Regulation of Systemic Inflammation Kevin Tracey, USA Intravenous Immuneglobulin Therapy in Sepsis with Special Emphasis on Severe Invasive Group A Streptococcal Infections Anna Norrby-Teglund, Sweden Recent Developments in the Identification of Novel Therapeutic Targets for the Treatment of Patients with Sepsis and Septic Shock Jonathan Cohen, UK |
| 15:00 p.m. | Farewell snacks |
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