Biological Function of the Gangliosides (1992, NS 83) Lars Svennerholm August 2-6, IBM Nordic Education Center, Elfvik, Lidingö Proceedings: Lars Svennerholm and others: Progress in Brain Research. Biological Function of Gangliosides (1994), Elsevier Science Ltd., Amsterdam, The Netherlands ISBN 0-444-81658-5 (vol) ISBN 0-444-80104-9 (series)

 

Table of Contents
List of Contributors	V
Preface	IX
Designation and schematic structure of gangliosides and allied glycosphingolipids Lars Svennerholm, Sweden	XI
Adhesion and counteradhesion: morphogenetic functions of the cell surface (Plenary lecture) Gerald Edelman, USA	1
Section I - Structure and Metabolism of Gangliosides
Ganglioside metabolism: enzymology, topology and regulation Konrad Sandhoff and Gerhild van Echten, Germany	17
Development regulation of ganglioside metabolism Robert K. Yu, USA	31
New mass spectral approaches to ganglioside structure determinations Catherine E. Costello, Peter Juhasz, and Hélène Perreault, USA	45
Principles of glycosphingolipid-oligosaccharide constitution Herbert Wiegandt, Germany	63
Section II - Gangliosides in Neuronal Differentiation and Development
Ganglioside turnover and neural cells function: a new perspective Guido Tettamanti and Laura Riboni, Italy	77
Gangliosides as modulators of neuronal calcium Gusheng Wu and Robert W. Ledeen, USA	101
Cell adhesion molecule (NCAM and N-cadherin)-dependent neurite outgrowth is modulated by gangliosides Frank S. Walsh, Stephen D. Skaper and Patrick Doherty, UK and Italy	113
Significance of ganglioside-mediated glycosignal transduction in neuronal differentiation and development Yoshitaka Nagai and Shuichi Tsuji, Japan	119
Ca2+-ganglioside-interaction in neuronal differentiation and development Hinrich Rahmann, Harald Rösner, Karl-Heinz Körtje, Heinz Beitinger and V. Seybold, Germany	127
Section III - Receptor and Cell Surface Activities of Gangliosides
A GMl-Ganglioside-binding protein in rat brain Donald A. Siegel and Kunihiko Suzuki, USA	149
Receptors for cholera toxin and Escherichia coli heat-labile enterotoxin revisited Jan Holmgren, Sweden	163
Carbohydrate ligands of leukocyte adhesion molecules and their therapeutic potential James C. Paulson, USA	179
Receptors for gangliosides and related glycosphingolipids on central and peripheral nervous system cell membranes Ronald L. Schnaar, James A. Mahoney, Patti Swank-Hill, Michael Tiemeyer and Leila K. Needham, USA	185
Section IV - Gangliosides and Cancer
Potential of genetically engineered anti-ganglioside GD2 antibodies for cancer immunotherapy Ralph A. Reisfeld, Barbara M. Mueller, Rupert Handgretinger, Alice L. Yu and Stephen D. Gillies, USA	201
Detection of glioma-associated gangliosides GM2, GD2, GD3, 3'-isoLM1 and 3',6'-isoLD1 in central nervous system tumors in vitro and in vivo using epitope-defined monoclonal antibodies C.J. Wikstrand, P. Fredman, L. Svennerholm and D.D. Bigner, USA and Sweden	213
Gangliosides associated with primary brain tumors and their expression in cell lines established from these tumors Pam Fredman, Sweden	225
Role of gangliosides in tumor progression Sen-itiroh Hakomori, USA	241
Tumor gangliosides as targets for active specific immunotherapy of melanoma in man Donald L. Morton, Mepur H. Ravindranath and Reiko F. Irie, USA	251
Section V - Gangliosides and Peripheral Neuropathies
Gangliosides and peripheral neuropathies: an overview Arthur K. Asbury, USA	279
The structure of human anti-ganglioside antibodies Donald M. Marcus and Nanping Weng, USA	289
Antibodies to glycoconjugates in neuropathy and motor neuron disease Norman Latov, USA	295
Gangliosides and related glycoconjugates in myelin: relationship to peripheral neuropathies A.J. Steck, D. Burger, S. Picasso, T. Kuntzer. E. Nardelli and M. Schluep, Switzerland and Italy	305
Antiglycolipid antibodies and peripheral neuropathies: links to pathogenesis John W. Griffin, USA	313
Section Vl - Gangliosides and Functional Recovery of Injured Nervous System
CNS Pharmacology of gangliosides Giancarlo Pepeu, Barbara Oderfeld-Nowak and Fiorella Casamenti, Italy and Poland	327
Cooperative effects of gangliosides on trophic factor-induced neuronal cell recovery and synaptogenesis: studies in rodents and subhuman primates A. Claudio Cuello, Lorella Garofalo, Paolo Liberini and Dusica Maysinger, Canada	337
Gangliosides in the protection against glutamate excitotoxicity E. Costa, D.M. Armstrong, A. Guidotti, A. Kharlamov, L. Kiedrowski, H. Manev, A. Polo and J.T. Wroblewski, USA and Italy	357
Clinical approaches to dementia Guy M. McKhann, USA	375
Neuropathological changes in Alzheimer disease Robert D. Terry, USA	383
Ganglioside loss is a primary event in Alzheimer disease Type 1 Lars Svennerholm, Sweden	391
Subject Index	405