Nobelprize.org
Lists of Nobel Prizes and Laureates

 Toward a Molecular Basis of Alcohol Use and Abuse
(1993, NS 86)
Hans Jörnvall, Bengt Jansson
September 20-23, Nobel Forum, Stockholm
Proceedings: Bengt Jansson, Hans Jörnvall and others: Toward a Molecular Basis of Alcohol Use and Abuse (1994), Birkhäuser Verlag, Basel, Switzerland

ISBN 3-7643-2940-8 (Basel)
ISBN 0-8176-2940-8 (Boston)

 

Table of Contents  
Preface IX
Perspectives
Alcohol in human history
B.L. Vallee
1
Section 1: Neuropharmacological aspects
Reward and its control by dynorphin peptides
L. Terenius
9
Adaptation of signal transduction in brain
C. Alling, L. Gustavsson, C. Larsson, C. Lundqvist, D. Rodriguez and
P. Simonsson
19
Protein kinase C and adaptation to ethanol
R. Roivainen, B. Hundle and R. O. Messing
29
Molecular control of neuronal survival in the chick embryo
S. Biffo, G. Dechant, H. Okazawa and Y.-A. Barde
39
Effects of alcohol on gene expression in neural cells
N. Wilke, M. Sganga, S. Barhite and M. F. Miles
49
The role of the NMDA receptor in ethanol withdrawal
P. L. Hoffman and B. Tabakoff
61
Molecular diversity of glutamate receptors and their physiological functions
S. Nakanishi, M. Masu, Y: Bessho, Y. Nakajima, Y. Hayashi and R. Shigemoto
71
Multiple dopamine receptors: The D3 receptor and actions of substances of abuse
J.-C. Schwartz, J. Diaz, N. Griffon, D. Levesque, M.-P. Martres and P. Sokoloff
81
Molecular pharmacology of serotonin receptors
P. R. Hartig
93
Alcohol, the reward system and dependence
G. F. Koob, S. Rassnick, S. Heinrichs and F. Weiss
103
Section 2: Biological markers and special clinical features
Clinical aspects on molecular probes, markers and metabolism
U. Rydberg
115
Familial alcoholism: Family, twin adoption and high risk studies
J. Knop
121
Association strategies in substance abuse
G. R. Uhl
133
PET-determination of benzodiazepine receptor binding in studies on alcoholism
L. Farde, S. Pauli, J.-E. Litton, C. Halldin, J. Neiman and G. Sedvall
143
Serotonin, violent behavior and alcohol
M. Linnoila, M. Virkkunen, T. George, M. Eckardt, J.D. Higley, D. Nielsen and D. Goldman
155
Neuropeptides and alcohol addiction in monkeys
J. M. van Ree, M. Kornet and C. Goosen
165
The role of adenosine in mediating cellular and molecular responses to ethanol
I. Diamond and A. S. Gordon
175
Helicobacter pylori alcohol dehydrogenase
M. Salaspuro
185
Genetic polymorphism of cytochrome P450. Functional consequences and possible relationship to disease and alcohol toxicity
M. Ingelman-Sundberg, I. Johansson, I. Persson, M. Oscarson, Y. Hu, L. Bertilsson, M.-L. Dahl and F. Sjöqvist
197
Serotonin-altering medications and desire, consumption and effects of alcohol treatment implications
C.A. Naranjo and K.E. Bremner
209
Section 3: Enzymatic aspects
The alcohol dehydrogenase system
H. Jörnvall
221
Drug metabolism and signal transduction: Possible role of Ah receptor and arachidonic acid cascade in protection from ethanol toxicity
D.W. Nebert
231
Recruitment of enzymes and stress proteins as lens crystallins
J. Piatigorsky, M. Kantorow, R. Gopal-Srivastava and S. l. Tomarev
241
X-ray structure of PQQ-dependent methanol dehydrogenase
M. Ghosh, A. Avezoux, C. Anthony, K. Harlos and C. C. F. Blake
251
NMR, alcohols, protein solvation and protein denaturation
K Wüthrich
261
Crystallographic investigations of alcohol dehydrogenases
H. Eklund, S. Ramaswamy, B. V. Plapp, M. El-Ahmad, O. Danielsson, J.-O. Höög and H. Jörnvall
269
Retinoids and the alcohol dehydrogenase gene family
G. Duester
279
Alcohol and acetaldehyde dehydrogenase gene polymorphism and alcoholism
D.I.N. Sherman, R.J. Ward, A. Yoshida and T. J. Peters
291
Site-directed mutagenesis and enzyme properties of mammalian alcohol dehydrogenases correlated with their tissue distribution
J.-O. Höög, M. Estonius and O. Danielsson
301
Control of alcohol metabolism
B. V. Plapp
311
Angiotensin converting enzyme inhibitors and alcohol abuse
J. E. Riordan
323
Section 4: Clinical aspects and pharmacological approaches
Treatment of alcoholism
B. Jansson
333
Alcohol sensitivity and dependence
M. A. Schuckit
341
Treatment of alcoholism as a chronic disorder
C. P. O'Brien
349
Addiction and the potential for therapeutic drug development
P. A. J. Janssen
361
Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology
W.-M. Keung and B. L. Vallee
371
Potential gene therapy for alcoholism
R. O. Brady
383
Outlook: Prospects for alcoholism treatment
E. Gordis
395
Subject index 405

 

Share this:
To cite this page
MLA style: "Towards a Molecular Basis of Alcohol Use and Abuse". Nobelprize.org. Nobel Media AB 2014. Web. 16 Sep 2014. <http://www.nobelprize.org/nobel_organizations/nobelfoundation/symposia/medicine/ns86/index.html>

Recommended:

On 27 November 1895 Alfred Nobel signed his last will in Paris.

 

Try to save some patients and learn about human blood types!

 

Discover the 2012 awarded research on stem cells and cell signalling.