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  The Nobel Prize in Chemistry 2004

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2004 "for the discovery of ubiquitin-mediated protein degradation" jointly to Aaron Ciechanover, Avram Hershko and Irwin Rose

 
  Proteins that are marked for hacking into small pieces
 

 

It has long been clear how proteins are built up in the cell. But the opposite, how they are broken down, was long thought to be less exciting to study. This year's Nobel Laureates, Aaron Ciechanover, Avram Hershko and Irwin Rose, went against the stream and, at the beginning of the 1980s, discovered one of the cell's most important control mechanisms, controlled protein degradation.

 
prize winners
Irwin Rose
College of Medicine, University of California, Irvine, USA
Avram Hershko Rappaport Institute, Technion – Israel Institute of Technology Haifa, Israel Aaron Ciechanover Rappaport Institute, Technion – Israel Institute of Technology Haifa, Israel
The discovery was made at the beginning of the 1980s at the Fox Chase Cancer Center in Philadelphia, USA, jointly by the three scientists.


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