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  The Nobel Prize in Physiology or Medicine 2001     
       
 
 

Leland Hartwell

Leland Hartwell, born 1939.
Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Leland Hartwell used baker's yeast, Saccharomyces cerevisiae, as a model system for genetic studies of the cell cycle. In an elegant series of experiments 1970-71, he isolated yeast cells, in which genes controlling the cell cycle were altered (mutated). By this approach, he identified genes specifically involved in cell cycle control, so called CDC-genes (cell division cycle genes). One of these genes, designated CDC28, controls the first step in the progression through the G1-phase of the cell cycle (the function "start"). Hartwell also identified the fundamental role of "checkpoints" in cell cycle control. These checkpoints monitor that all steps in the previous phase have been correctly executed and ensure a correct order between the cell cycle phases.

 


Important model organisms for this year's Laureates. Leland Hartwell used baker's yeast, Saccharomyces cerevisiae (left). Paul Nurse used another type of yeast, Schizosaccharomyces pombe (middle). Tim Hunt used sea urchin, Arbacia (right).


 
   Contents:  
 
| The Nobel Prize in Physiology or Medicine 2001 | Introduction | Leland HartwellPaul Nurse |
Tim Hunt
| The Implications of the Discoveries |
Play the "Control of the Cell Cycle" game! 
Based on materials from the 2001 Nobel Poster for Physiology or Medicine
Credits  
Nobel Poster from the Nobel Committee for Physiology or Medicine, web adapted by Nobel Web
 


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