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  The Nobel Prize in Physiology or Medicine 2002     
       
 
  John Sulston
John Sulston, born 1942,
Cambridge, England.

John Sulston developed techniques to study all cell
divisions in C. elegans, from the fertilized egg to the
959 somatic cells in the adult nematode. In 1976, Sulston
described the cell lineage for a part of the developing
nervous system. He showed that the cell lineage is invariant,
i.e. every nematode undergoes exactly the same
programme of cell division and differentiation.

As a result of these findings, Sulston discovered that specific
cells in the cell lineage always die by programmed
cell death. This could be followed in the living organism.
He described the visible steps in the cellular death process
and demonstrated the first mutation of a gene participating
in programmed cell death, the nuc-1 gene.


John Sulston mapped a cell lineage in the nematode C. elegans. He showed that specific cells undergo programmed cell death during the normal differentiation process.
   
 
   Contents:  
 
|The Nobel Prize in Physiology or Medicine 2002 | Introduction | Sydney BrennerRobert Horvitz |
John Sulston
| The Implications of the Discoveries | Credits |
Nobel Poster from the Nobel Committee for Physiology or Medicine, web adapted by Nobel Web
 


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