Lists of Nobel Prizes and Laureates

Towards an Understanding of Integrative Brain Functions

Gap junction wiring: a 'new' principle in cell-to-cell communication in the nervous system?

Rolf Dermietzel*
Institute of Anatomy, University of Regensburg, Universitätsstr. 31, 93052 Regensburg, Germany

This review gives an updated excerpt of recent advances in our understanding of brain gap junctions. It starts with a brief description of the principle molecular composition of gap junctions before specific issues concerning brain tissues are addressed. The following questions and matters are subjected to a detailed analysis: First, why are there so many gap junctions in the brain? Second, what is the functional significance of the cellular diversity of brain gap junctions? Third, how do astrocytic gap junctions mediate intercellular volume tansmission (IVT), and what does IVT mean for glial-neuronal interaction? Fourth, how frequent are interneuronal gap junctions; and what is their functional significance in brain development and in interrelated chemical-eletrotonic transmission at mixed synapses.

*Corresponding author:

Brain Research Reviews 26 (1998) 176-183
Copyright © 1998 Elsevier Science B. V. All rights reserved.


Share this:
To cite this page
MLA style: "Gap junction wiring: a new principle in cell-to-cell communication in the nervous system?". Nobel Media AB 2014. Web. 21 Sep 2017. <>