Activation and Inactivation of the G Protein



1. The G protein, composed of alpha-, beta- and gamma-subunits, in its resting state with bound GDP. 2. The receptor with bound hormone activates the G protein and replaces GDP...
3. ...with GTP and the G proteins is activated. The subunits separate. 4. Some seconds later the GTP, bound to the alpha-subunit, is hydrolysed to GDP. The subunits recombine.

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