The Nobel Prize in Chemistry 1958
Frederick Sanger was born on
August 13, 1918, at Rendcombe in Gloucestershire, the second son
of Frederick Sanger, M.D., a medical practitioner and his wife
Cicely. He was educated at Bryanston School and at St. John's
College, Cambridge, where he took his B.A. degree in natural
sciences in 1939. Since 1940 he has carried out research in the
Department of Biochemistry at Cambridge. From 1940 to 1943 he
worked with Dr. A. Neuberger on the metabolism of the amino acid
lysine and obtained a Ph.D. degree in 1943. From 1944 to 1951 he
held a Beit Memorial Fellowship for Medical Research and since
1951 he has been a member of the External Staff of the Medical
Research Council. His present position is Head of the Division of
Protein Chemistry in the M.R.C. Laboratory for Molecular Biology
Since 1943 his work has been concerned largely with problems related to the determination of the structure of proteins. These studies resulted in the determination of the structure of insulin.
Sanger was awarded the Corday-Morgan Medal and Prize of the Chemical Society in 1951. In 1954 he became a Fellow of the Royal Society and a Fellow of King's College, Cambridge. He is an Honorary Foreign Member of the American Academy of Arts and Sciences; Honorary Member of the American Society of Biological Chemists, Member of the Academies of Science of Argentina and Brazil, Honorary Member of the Japanese Biochemical Society, and Corresponding Member of the Association Qulmica Argentina.
In 1940, he married Margaret Joan Howe; they have two sons and one daughter.
From Nobel Lectures, Chemistry 1942-1962, Elsevier Publishing Company, Amsterdam, 1964
This autobiography/biography was written at the time of the award and first published in the book series Les Prix Nobel. It was later edited and republished in Nobel Lectures. To cite this document, always state the source as shown above.Copyright © The Nobel Foundation 1958
Following the work on insulin he developed further methods
for studying proteins and particularly the active centres of some enzymes.
Around 1960 he turned his attention to the nucleic acids, RNA and DNA. He developed
methods for determining small sequences in RNA. The work culminated in the
development of the "dideoxy" technique for DNA sequencing around
1975. This was a relatively rapid method and was used to determine the DNA
sequence of the bacteriophage fx 174 of 5375
nucleotides in 1977, of human mitochrondrial DNA (16,338 nucleotides) and of
bacteriophage l (48,500
nucleotides). The method has been improved and automated in other human genome
(3 billion nucleotides).
Sanger retired in 1983.
Frederick Sanger received a second Nobel Prize in Chemistry in 1980.
Frederick Sanger died on 19 November 2013.
Copyright © The Nobel Foundation 2005