Dorothy Crowfoot Hodgkin
Born: 12 May 1910, Cairo, Egypt
Died: 29 July 1994, Shipston-on-Stour, United Kingdom
Affiliation at the time of the award: University of Oxford, Royal Society, Oxford, United Kingdom
Prize motivation: "for her determinations by X-ray techniques of the structures of important biochemical substances"
Field: biochemistry, structural chemistry
Prize share: 1/1
When X-rays pass through a crystalline structure, the patterns formed can be captured as photographic images, which are then used to determine the crystal's structure. During the 1930s, this method was used to map increasingly large and complex molecules. A mass of X-ray diffraction images, extensive calculations, and astute analysis helped Dorothy Crowfoot Hodgkin to successfully determine the structure of penicillin in 1946 and, in 1956, also the structure of vitamin B12, which has the most complex structure of all vitamins.