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Nobel Prizes and Laureates

Nobel Prizes and Laureates

The Nobel Prize in Chemistry 1972
Christian Anfinsen, Stanford Moore, William H. Stein

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William H. Stein - Facts

William H. Stein

William H. Stein

Born: 25 June 1911, New York, NY, USA

Died: 2 February 1980, New York, NY, USA

Affiliation at the time of the award: Rockefeller University, New York, NY, USA

Prize motivation: "for their contribution to the understanding of the connection between chemical structure and catalytic activity of the active centre of the ribonuclease molecule"

Field: analytical biochemistry, biochemistry

Prize share: 1/4

Work

The genetic information of an organism is stored in DNA molecules which, via RNA molecules, are converted during the formation of proteins. The chemical processes inside cells are controlled by a type of protein called enzymes. William Stein and Stanford Moore studied the enzyme ribonuclease, which divides RNA into smaller components. In the late 1950s, the pair succeeded in providing a detailed understanding of the enzyme's active center and in elucidating the connection between the structure of the molecule and its ability to speed up biochemical reactions.

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