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The Nobel Prize in Physiology or Medicine 2013
James E. Rothman, Randy W. Schekman, Thomas C. Südhof

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James E. Rothman - Facts

James E. Rothman

James E. Rothman

Born: 3 November 1950, Haverhill, MA, USA

Affiliation at the time of the award: Yale University, New Haven, CT, USA

Prize motivation: "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells"

Field: biochemistry, cell physiology

Prize share: 1/3

Mapping of the Cell's Transport System

The cells inside our bodies produce a host of different molecules that are sent to specific sites. During transport, many of these molecules are grouped together in tiny sac-like structures called vesicles. These vesicles help transport substances to different places inside the cell and send molecules from the cell's surface as signals to other cells in the body.

During the 1980s and 1990s, James Rothman showed how vesicles fuse with specific surfaces in the cell so that transports arrive at the correct destination.

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