The Nobel Prize in Chemistry 1985
Herbert A. Hauptman, Jerome Karle
I was born in New York City in 1918 into
a family that had a number of artistic people among its members.
My father's brother and a sister's husband were probably the best
known. The latter, Ivan Olinsky, taught for many years at the Art
Students' League in New York City. I have been told that my
paternal grandfather professionally made artistic decorations in
peoples' homes. The propensity for artistic endeavors extended to
my generation and beyond.
My mother was an excellent pianist and organist and it was one of her hopes that I would become a professional pianist. As a youth I was entered into "Music Week" competitions in New York City. I had some modest success, but found at an early age that I had no taste for public performance. On the other hand, I was strongly attracted to science as a lifelong career at an early age.
I had the privilege of attending schools in the New York City public school system. Their standards of education, character building and discipline were very high and I, most certainly, benefited from them. They separated out the more advanced students and permitted them to progress at their own pace. In my case, this occasionally led to some curious circumstances. In my senior year in high school (Abraham Lincoln), the girls would join the boys to practice dancing. I was 14 years old at the time and the girls were the usual 17-18 years old. The physical discrepancy between this 14 year old boy and 17-18 year old girls was considerable. Their first reaction was incredulity but after a while they got used to my presence and even danced with me. I took the chemistry and physics courses that were available, both taught by the same man. He recognized my interests and was very encouraging to me.
I enjoyed a number of sports that I participated in at every opportunity, swimming in the ocean nearby, a game called single-wall handball, played with a little hard black ball and well-known mainly in some metropolitan areas, touch football whose rules eliminate the bruises from tackling and ice-skating that was facilitated by the flooding of a huge parking lot by the local fire department.
I entered the City College of New York in 1933 and, at first, found it to be a bit of a struggle. Their academic standards were very high and they had a concentration of the best students in New York City. In addition, I spent three hours a day traveling on the subway system to and from home. This marked the end of piano practicing. City College had no tuition fee. The only financial requirement was one dollar per year for a library card. At the College, there were broad course requirements for all students that ranged through mathematics, the physical sciences, the social sciences and literature. There were even two years of compulsory public speaking courses. I studied, in addition to the requirements, some additional mathematics, some physics, and much chemistry and biology. The year after graduation from City College was spent at Harvard University in the study of biology, for which I received a master's degree, M.A., in 1938.
After a brief hiatus, I went to work with the New York State Health Department in Albany. While there, I had the opportunity to spend some time again at the piano. At the time I was in Albany, the fluoridation of drinking water was getting underway. I developed a procedure for determining the amount of fluorine in water supplies that became a standard method. This was my first modest contribution to science.
It was my intention to save enough money while at the Health Department to return to graduate school. This I did, and I entered the Chemistry Department of the University of Michigan in 1940 where I met my wife, Isabella Lugoski, whom I married in 1942, at an adjoining laboratory desk the first day that I went to physical chemistry class. We were both attracted to physical chemistry and took our degrees with Professor Lawrence O. Brockway whose speciality was the investigation of gas-phase molecular structure by means of electron diffraction. Although my Ph.D. degree was awarded in 1944, I had completed all my work for it during the summer of 1943 and went off to work on the Manhattan Project at the University of Chicago. Isabella joined me on this project a few months later.
In 1944, we returned to the University of Michigan, I went to work on a project of the Naval Research Laboratory and Isabella as an instructor in the Chemistry Department. While at the University of Michigan, I performed some experiments on the structure of monolayers of long-chain hydrocarbon films involved in the boundary lubrication of metallic surfaces. I also derived a theory that explained the electron diffraction patterns obtained from the oriented monolayers.
In 1946 we both went to work permanently in Washington for the Naval Research Laboratory. Our interest continued in developing the quantitative aspects of gas electron diffraction analysis. The solution of a key problem that arose in such analyses had evident implications for crystal structure analysis and, in fact, other areas of structure determination. At about the time that these matters were developing, Herbert Hauptman joined us at the Naval Research Laboratory and we decided to pursue the implications for crystal structures. This eventually led to the development of the direct methods for crystal structure analysis with the major part of the mathematical foundations and procedural insights established in the early 1950's.
While all this was going on and with hardly missing a step from her research activities, Isabella mothered three children, Louise in 1946, Jean in 1950, and Madeleine in 1955. Louise is a theoretical chemist, Jean an organic chemist and Madeleine is a museum specialist trained in geology.
The initial applications of the procedure for structure determination for centrosymmetric crystals involving probability measures and formulas derived from the joint probability distribution were performed in the middle 1950's in collaboration with colleagues at the U.S. Geological Survey. Then, in the second half of the 1950's, through the efforts of Isabella Karle, an experimental X-ray diffraction facility was established in our own laboratory.
During the 1960's, there was an intensive program in my laboratory to develop a procedure for crystal structure determination of broad applicability that would encompass noncentrosymmetric as well as centrosymmetric crystals. Largely through the efforts of Isabella Karle, such a procedure was developed and called the symbolic addition procedure. This procedure had its origins in the theoretical work and the experience in practical application of the 1950's, but it also required some new procedural insights and some additional theoretical work to make it efficient and broadly applicable and avoid the pitfalls that easily arise when optimal pathways through a procedure must be chosen on the basis of probability measures. The first application of the symbolic addition procedure was published in 1963 and the first essentially equal atom noncentrosymmetric crystal structure to be solved by direct phase determination was published in 1964. This was followed by a number of exciting applications and toward the end of the 1960's many laboratories started to become interested in the potential of the direct method for structure determination.
During the 1960's, I collaborated with Isabella in some of her investigations and derived with her a variance formula that was the basis for applying probability measures to procedures for analyzing noncentrosymmetric crystals. In addition, I also carried out a number of theoretical investigations. Perhaps, the most useful one concerned a procedure for developing a fragment of a structure into a complete one by use of the so-called tangent formula for phase determination.
During the 1950's and 1960's, I maintained an interest in gas electron diffraction and made some experimental and theoretical studies of internal rotation and coherent diffraction associated with excitation processes. The latter was especially interesting, but required extensive experimental development that the resources available to me did not permit.
In the 1970's, I continued theoretical work in crystal structure analysis that included the derivation of a "tangent formula" for phase determination that was based on the more restrictive higher and higher order determinants from the determinantal inequalities. I showed how joint probability distributions relevant to crystallographic quantities could be put into an exponential form and thereby decrease considerably problems with asymptotic convergence. I also derived heuristic joint probability distributions based on the determinants involved in the determinantal inequalities and obtained from them formulas for evaluating triplet phase invariants and, later on, formulas for the expected values of phase invariants and embedded semi-invariants of any order, triplet, quartet, quintet, etc. The utility of phase invariants of high order in phase determination has so far been rather limited, except perhaps collectively in the high order determinants where they have been useful for refining the values of approximately determined phase values.
I participated with Wayne Hendrickson of my laboratory in some refinements of macromolecular structure with the use of the tangent formula and also had some early participation with John Konnert and Wayne Hendrickson in the constrained refinement technique for macromolecules. In collaboration with John Konnert and Peter D'Antonio, procedures were developed for determining atomic arrangements in amorphous materials based on criteria similar to those applied to molecular vapors. Collaborations on structural problems also included Judith Flippen-Anderson, Clifford George, Richard Gilardi and Alfred Lowrey.
At the end of the 1970's Wayne Hendrickson made some valuable advances in the application of anomalous dispersion to the determination of macromolecular structure that rekindled an interest that I formerly had in this subject. I developed an exact, linear algebraic theory that includes any number and type of anomalous scatterer and any number of wavelengths. It can also incorporate information from isomorphous replacement measurements. Exact data give exact values for the unknown quantities that include phase differences. I have also been investigating the evaluation of triplet phase invariants to see what their potential usefulness may be. This activity continues to the present and is greatly facilitated by Stephen Brenner who has performed my programming and computing for me since the early 1960's.
In addition to participating in the development of new analytical methods and their applications, I have taught from time to time, mathematics and physics in the University College of the University of Maryland, I have taken an active role in the affairs of crystallography over the years as, for example, President of the International Union of Crystallography (1981-1984) and have enjoyed having a laboratory that investigates a broad variety of subjects ranging over gaseous molecules, amorphous solids, fibers, crystals and crystalline macromolecules.
During my entire married life I have had the strong support of my wife, both technical and spiritual. I also deeply appreciate the supportive atmosphere provided by the Naval Research Laboratory. This was especially helpful during the early 1950's when a large number of fellow-scientists did not believe a word we said.
From Les Prix Nobel. The Nobel Prizes 1985, Editor Wilhelm Odelberg, [Nobel Foundation], Stockholm, 1986
This autobiography/biography was written at the time of the award and later published in the book series Les Prix Nobel/Nobel Lectures. The information is sometimes updated with an addendum submitted by the Laureate.Copyright © The Nobel Foundation 1985
Since this biography was written in 1985, advances have been made
in macromolecular structure analysis by applications of the
linear algebraic theory for the multiwavelength anomalous
dispersion technique that I published in 1980. A number of such
applications have been made by Wayne Hendrickson and colleagues
who, along with the applications, developed suitable techniques
for the use of synchrotron radiation and relatively weak
anomalous scatterers. In recent years, I have been concerned with
additional developments in the anomalous dispersion technique and
have become interested in some aspects of the solution of
nonlinear simultaneous equations, the determination of electron
densities in crystals and some new approaches to phase
determination in crystal structure problems.
Receipt of the Nobel Prize has given me the opportunity to have contact to an unprecedented degree with young people who look forward to careers in science and other intellectual and artistic pursuits. I have also had many contacts with organizations whose purpose is to improve the quality of life on this planet in a variety of contexts. These contacts have not changed my earlier views, but, in many instances, have perhaps given some of them a sharper focus. I would like to share a few.
Societies must provide a framework of encouragement in which its children can develop their skills fully and an educational system open to all in which this can be achieved. In many societies with which I am familiar, this would require a major change of priorities. Encouragement within the family structure is also very important.
This world has enormous social, economic and political problems, not the least of which concern the environment and natural resources. The degradation of the environment must be brought under control if there is to be a worthwhile and sustainable quality of life for most people. This too will require a reordering of priorities. It is very likely that continued population growth will defeat any attempts to halt environmental degradation and the unconscionable destruction of resources. Everyone has a responsibility in this regard.
Respect for the dignity of all human beings, if widespread, would go very far toward relieving numerous social stresses that much too often lead to societal deterioration and violence.
Our world has a long way to go.
Since the time of my receipt of the Nobel Prize in 1985, as you undoubtedly know, my life has changed considerably. I have written about it up to 1992. I have now prepared an additional addendum that reaches to the present (March, 2006).
My wife, Isabella, and I still go to work regularly at the Naval Research Laboratory in Washington, D.C. Although we collaborated several times in the past, I have been mainly concerned with the use of quantum mechanics to facilitate the solution of problems in chemistry that heretofore were quite limited because of their complexity. There are several publications which have included myself, a member of my research group, Dr. Lulu Huang, and Prof. Lou Massa of the City University of New York.
Some of the most attractive features of obtaining a Nobel Prize in science is the opportunities that express themselves in invitations to participate in important issues and activities which arise in the form of meetings of distinguished persons who also take the time to encourage young people to commit themselves to a life in science. A perfect example of the latter is the yearly meetings of Nobel Laureates in science and students in Lindau, Germany. I have had the very pleasant privilege of engaging in both types of activities.
Poland is another country in which, for some years, my wife and I participated in one of their yearly lecture programs. My wife's parents came from Poland, and although she was born in Detroit, Michigan, she spoke only Polish until she started elementary school at the age of seven. One year, when we were in Poland we made a visit to a mining town for unusual minerals, Przebenia, where my father was born. The lady who was the mayor put together for us a variety of items describing the history of the town and its many features, a most kindly effort on our behalf.
I should mention that my research program has changed very much over the years. The main objective now is to develop a broad and detailed understanding of how nature operates in carrying out the processes that are known to occur in the human body. Of course, many such processes are understood to a certain extent but there are many processes that are only partially known or not at all well understood. This is not a project that is generally easily or rapidly solved. Some progress has been made in developing methods for discovering the properties of important substances such as proteins which may lead, in time, to a better understanding of the processes in which such substances play a major role.
Jerome Karle died on 6 June 2013.
Copyright © The Nobel Foundation 2006