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The Nobel Prize in Chemistry 2004
Aaron Ciechanover, Avram Hershko, Irwin Rose

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The Laureates
Aaron Ciechanover, Technion (Israel Institute of Technology)
Avram Hershko, Technion (Israel Institute of Technology)
 
Original Papers
Ciechanover, A., Hod, Y., and Hershko, A. (1978) "A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes". Biochem. Biophys. Res. Commun. 81, pp. 1100-1105.
Hershko, A., Ciechanover, A., and Rose, I.A. (1979) "Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP". Proc. Natl. Acad. Sci. USA 76, pp. 3107-3110.
Ciechanover, A., Heller, H., Elias, S., Haas, A.L., and Hershko, A. (1980) "ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation". Proc. Natl. Acad. Sci. USA 77, pp. 1365-1368.
Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". Proc. Natl. Acad. Sci. USA 77, pp. 1783-1786.
Ciechanover, A., Heller, H., Katz-Etzion, R., and Hershko, A. (1981) "Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system". Proc. Natl. Acad. Sci. USA 78, pp. 761-765.
Hershko, A., Heller, H., Elias, S., and Ciechanover, A. (1983) "Components of ubiquitin-protein ligase system". J. Biol. Chem. 258, pp. 8206-8214.
 
Other Articles
Ciechanover, A. (1998) "The ubiquitin-proteasome pathway: on protein death and cell life". EMBO J., 17, pp. 7151-7160.
Goldberg, A.L., Elledge, S.J. and Harper, J.W. (2001) "The cellular chamber of doom". Scientific American, Jan 284 (1), pp. 56-61.
Hershko, A. and Ciechanover, A. (1998) "The ubiquitin system". Annu. Rev. Biochem 67, pp. 425-479.
Weissman, A.M. (2001) "Themes and variations on ubiquitylation". Nature reviews Molecular cell biology 2, pp. 169-178.

 

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