The Nobel Prize in Physiology or Medicine 1901
Emil von Behring
Behring was born on March 15, 1854 at Hansdorf, Deutsch-Eylau
as the eldest son of the second marriage of a schoolmaster with a
total of 13 children. Since the family could not afford to keep
Emil at a University, he entered, in 1874, the well-known Army
Medical College at Berlin. This made his studies financially
practicable but also carried the obligation to stay in military
service for several years after he had taken his medical degree
(1878) and passed his State Examination (1880). He was then sent
to Wohlau and Posen in Poland. Besides much practical work he
found in Posen time to study (at the Chemical Department of the
Experimental Station) problems connected with septic diseases. In
the years 1881-1883 he carried out important investigations on
the action of iodoform, stating that it does not kill microbes
but may neutralize the poisons given off by them, thus being
antitoxic. His first publications on these questions appeared in
1882. The governing body concerned with military health, which
was especially interested in the prevention and combating of
epidemics, being aware of the ability of Behring, sent him to the
pharmacologist C. Binz at Bonn for further training in
experimental methods. In 1888 they ordered him back to Berlin,
where he worked-undoubtedly in full agreement with his own wishes
- as an assistant at the Institute of Hygiene under Robert Koch.
He remained there for several years after 1889, and followed Koch
when the latter moved to the Institute for Infectious Diseases.
This appointment brought him into close association, not only
with Koch, but also with P. Ehrlich, who joined, in 1890, the
brilliant team of workers Koch had gathered round him. In 1894
Behring became Professor of Hygiene at Halle, and the following
year he moved to the corresponding chair at Marburg.
Behring's most important researches were intimately bound up with the epoch-making work of Pasteur, Koch, Ehrlich, Löffler, Roux, Yersin and others, which led the foundation of our modern knowledge of the immunology of bacterial diseases; but he is, himself, chiefly remembered for his work on diphtheria and on tuberculosis. During the years 1888-1890 E. Roux and A. Yersin, working at the Pasteur Institute in Paris, had shown that filtrates of diphtheria cultures which contained no bacilli, contained a substance which they called a toxin, that produced, when injected into animals, all the symptoms of diphtheria. In 1890, L. Brieger and C. Fraenkel prepared, from cultures of diphtheria bacilli, a toxic substance, which they called toxalbumin, which when injected in suitable doses into guinea-pigs, immunized these animals to diphtheria.
Starting from his observations on the action of iodoform, Behring tried to find whether a disinfection of the living organism might be obtained if animals were injected with material that had been treated with various disinfectants. Above all the experiments were performed with diphtheria and with tetanus bacilli. They led to the well-known development of a new kind of therapy for these two diseases. In 1890 Behring and S. Kitasato published their discovery that graduated doses of sterilised brothcultures of diphtheria or of tetanus bacilli caused the animals to produce, in their blood, substances which could neutralize the toxins which these bacilli produced (antitoxins). They also showed that the antitoxins thus produced by one animal could immunize another animal and that it could cure an animal actually showing symptoms of diphtheria. This great discovery was soon confirmed and successfully used by other workers.
Earlier in 1898, Behring and F. Wernicke had found that immunity to diphtheria could be produced by the injection into animals of diphtheria toxin neutralized by diphtheria antitoxin, and in 1907 Theobald Smith had suggested that such toxin-antitoxin mixtures might be used to immunize man against this disease. It was Behring, however, who announced, in 1913, his production of a mixture of this kind, and subsequent work which modified and refined the mixture originally produced by Behring resulted in the modern methods of immunization which have largely banished diphtheria from the scourges of mankind. Behring himself saw in his production of this toxin-antitoxin mixture the possibility of the final eradication of diphtheria; and he regarded this part of his efforts as the crowning success of his life's work.
From 1901 onwards Behring's health prevented him from giving regular lectures and he devoted himself chiefly to the study of tuberculosis. To facilitate his work a commercial firm in which he had a financial interest, built for him well-equipped laboratories at Marburg and in 1914 he himself founded, also in Marburg, the Behringwerke for the manufacture of sera and vaccines and for experimental work on these. His association with the production of sera and vaccines made him financially prosperous and he owned a large estate at Marburg, which was well stocked with cattle which he used for experimental purposes.
The great majority of Behring's numerous publications have been made easily available in the editions of his Gesammelte Abhandlungen (Collected Papers) in 1893 and 1915.
Numerous distinctions were conferred upon Behring. Already in 1893 the title of Professor was conferred upon him, and two years later he became «Geheimer Medizinalrat» and officer of the French Legion of Honour. In the ensuing years followed honorary membership of Societies in Italy, Turkey and France; in 1901, the year of his Nobel Prize, he was raised to the nobility, and in 1903 he was elected to the Privy Council with the title of Excellency. Later followed further honorary memberships in Hungary and Russia, as well as orders and medals from Germany, Turkey and Roumania. He also became an honorary freeman (Ehrenbürger) of Marburg.
In 1896 Behring married the 18 years old Else Spinola, daughter of the Director of the Charité at Berlin. They had seven children. Behring died at Marburg on March 31, 1917.
From Nobel Lectures, Physiology or Medicine 1901-1921, Elsevier Publishing Company, Amsterdam, 1967
This autobiography/biography was written at the time of the award and first published in the book series Les Prix Nobel. It was later edited and republished in Nobel Lectures. To cite this document, always state the source as shown above.
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