Nobel Prizes and Laureates

Nobel Prizes and Laureates

The Nobel Prize in Physiology or Medicine 1992
Edmond H. Fischer, Edwin G. Krebs

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Edwin G. Krebs - Facts

Edwin G. Krebs

Edwin G. Krebs

Born: 6 June 1918, Lansing, IA, USA

Died: 21 December 2009, Seattle, WA, USA

Affiliation at the time of the award: University of Washington, Seattle, WA, USA

Prize motivation: "for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism"

Field: biochemistry, cell physiology

Prize share: 1/2


The element phosphorus and phosphate groups, consisting of phosphorous and oxygen atoms, play an important role in several vital biochemical processes. In the mid-1950s Edwin Krebs and Edmond Fischer were able to describe how processes in which proteins emit and absorb phosphate groups can take place in both directions. They demonstrated how the process is governed by special enzymes - proteins that speed up the transformation of other proteins without being incorporated in the final products of the process. These processes are important in the regulation of metabolism in the body and other functions.

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