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Edwin G. Krebs
The Nobel Prize in Physiology or Medicine 1992
Born: 6 June 1918, Lansing, IA, USA
Died: 21 December 2009, Seattle, WA, USA
Affiliation at the time of the award: University of Washington, Seattle, WA, USA
Prize motivation: "for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism."
Prize share: 1/2
The element phosphorus and phosphate groups, consisting of phosphorous and oxygen atoms, play an important role in several vital biochemical processes. In the mid-1950s Edwin Krebs and Edmond Fischer were able to describe how processes in which proteins emit and absorb phosphate groups can take place in both directions. They demonstrated how the process is governed by special enzymes - proteins that speed up the transformation of other proteins without being incorporated in the final products of the process. These processes are important in the regulation of metabolism in the body and other functions.
Their work and discoveries range from cancer therapy and laser physics to developing proteins that can solve humankind’s chemical problems. The work of the 2018 Nobel Laureates also included combating war crimes, as well as integrating innovation and climate with economic growth. Find out more.