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Nobel Prizes and Laureates

Nobel Prizes and Laureates

The Nobel Prize in Physiology or Medicine 2006
Andrew Z. Fire, Craig C. Mello

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Craig C. Mello - Facts

Craig C. Mello

Craig C. Mello

Born: 19 October 1960, New Haven, CT, USA

Affiliation at the time of the award: University of Massachusetts Medical School, Worcester, MA, USA

Prize motivation: "for their discovery of RNA interference - gene silencing by double-stranded RNA"

Field: genetics, molecular biology

Prize share: 1/2

Work

RNA has multiple functions. Among these, "messenger RNA" carries genetic information from DNA to protein formation. RNA is often a single-stranded spiral, but also exists in double-stranded form. In 1998, Craig Mello and Andrew Fire discovered through their studies of the roundworm C. elegans a phenomenon dubbed "RNA interference". In this phenomenon, double-stranded RNA blocks messenger RNA so that certain genetic information is not converted during protein formation. This "silences" these genes, i.e. renders them inactive. The phenomenon plays an important regulatory role within a genome.

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MLA style: "Craig C. Mello - Facts". Nobelprize.org. Nobel Media AB 2014. Web. 30 May 2017. <http://www.nobelprize.org/nobel_prizes/medicine/laureates/2006/mello-facts.html>

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