Schack August Steenberg Krogh
Born: 15 November 1874, Grenå, Denmark
Died: 13 September 1949, Copenhagen, Denmark
Affiliation at the time of the award: Copenhagen University, Copenhagen, Denmark
Prize motivation: "for his discovery of the capillary motor regulating mechanism"
Field: cardiovascular physiology, muscle physiology
Prize share: 1/1
August Krogh was born in Grenå, Denmark, where his father worked as a shipbuilder. He studied medicine and zoology at the University of Copenhagen and, in 1897, began working for physiologist Christian Bohr in Bohr's laboratory. August Krogh maintained ties with the University of Copenhagen until his retirement in 1945. Though retired, he continued researching in his own private laboratory for several years. August Krogh carried out much of his work in collaboration with his wife, Marie. August and Marie Krogh had four children.
One of the circulatory system's most important functions is carrying oxygen to muscles. August Krogh developed methods for precisely measuring blood oxygen levels and explained how oxygen supply to muscles is regulated based on workload. Previously, it was thought that it was the blood's rate of flow that increased during exertion. During the 1910s, however, August Krogh showed that it was rather oxygen flow that was regulated by the opening of smaller blood vessels, capillaries. When resting, relatively few capillaries are open.
"for the discovery of the role played by the sinus and aortic mechanisms in the regulation of respiration"
"for his discovery relating to the production of heat in the muscle"
"for their discoveries concerning heart catheterization and pathological changes in the circulatory system"