Born: 21 January 1912, Neisse (now Nysa), Germany (now Poland)
Died: 15 October 2000, Burlington, MA, USA
Affiliation at the time of the award: Harvard University, Cambridge, MA, USA
Prize motivation: "for their discoveries concerning the mechanism and regulation of the cholesterol and fatty acid metabolism"
Field: biochemistry, metabolism, physiology
Prize share: 1/2
Cholesterol is an important component in the body's cells and plays a major role in several biochemical processes. Konrad Bloch and Feodor Lynen and their respective colleagues investigated how cholesterol and fatty acids are formed and converted in the body. Among other things, they showed that acetic acid is an important component in cholesterol and how the formation occurs in reactions with many steps. This knowledge is important for an understanding of heart disease and other illnesses in which changes in cholesterol formation can play a role.
"for their discoveries concerning the regulation of cholesterol metabolism"
"for his discoveries in connection with the biological combustion processes, with special reference to vitamin C and the catalysis of fumaric acid"
"for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism"