Joseph L. Goldstein
Born: 18 April 1940, Sumter, SC, USA
Affiliation at the time of the award: University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Prize motivation: "for their discoveries concerning the regulation of cholesterol metabolism"
Field: metabolism, physiology
Prize share: 1/2
Cholesterol is an important component in the body's cells and plays an important role in several biochemical processes. Too much cholesterol in the blood can cause problems, however, by forming strictures in blood vessels. In 1973 Joseph Goldstein and Michael Brown discovered the receptor, or receiver, in cells that takes in cholesterol and clarified how the conversion of cholesterol is regulated by our genes and other substances. The discoveries became the basis for statins, medications that reduce cholesterol levels in the blood.
"for their discoveries concerning the mechanism and regulation of the cholesterol and fatty acid metabolism"
"for their discoveries of important principles for drug treatment"
"for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system"