Nobel Prize

Gerty Cori uncovered the process of cellular energy storage and release, answering one of the most fundamental questions about how the human body works. In so doing, she and her husband and lifelong research partner, Carl, transformed the study of biology, proving that the clarity of molecular chemistry could and should be applied to the opaque mechanisms of biology.

“Captured for life by chemistry and by crystals,” as she described it, Dorothy Hodgkin turned a childhood interest in crystals into the ground-breaking use of X-ray crystallography to “see” the molecules of penicillin, vitamin B12 and insulin. Her work not only allowed researchers to better understand and manufacture life-saving substances, it also made crystallography an indispensable scientific tool.

With the drugs that she created, Gertrude Elion fulfilled her life’s mission: to alleviate human suffering. Beyond the individual drugs she discovered, she pioneered a new, more scientific approach to drug development that forever altered – and accelerated – medical research.

Ever since she was a girl, Ada Yonath has set herself seemingly impossible goals, and then figured out how to reach them, step by step. As a young scientist she took on a challenge that others considered hopeless – mapping the structure of the ribosome – and persevered for decades until she succeeded. Her determination and ingenuity allowed researchers to see and understand the complex and crucial molecule. And since the ribosome is a major bacterial target for antibiotics, her work has led to new antibiotics and a better understanding of antibiotic resistance.

Throughout her career, Barbara McClintock studied the cytogenetics of maize, making discoveries so far beyond the understanding of the time that other scientists essentially ignored her work for more than a decade. But she persisted, trusting herself and the evidence under her microscope.

Rita Levi-Montalcini began her scientific career in danger, as a Jew in Fascist Italy. She ended it in triumph, as the neuroembryologist who co-discovered nerve growth factor, a prominent figure in Italian politics, and an active researcher and mentor until her death at the age of 103.

Linda Buck was fascinated by one seemingly simple question: how does our sense of smell work? Once she started to look for the answer, she didn’t let it go. She followed the olfactory process step by step to the very heart of what makes us human: our perceptions, preferences and memories.

Elizabeth Blackburn has evolved from a self-described “lab rat” to an explorer in the realms of health and public policy. She discovered the molecular structure of telomeres and co-discovered the enzyme telomerase, essential pieces in the puzzle of cellular division and DNA replication.

With one ingenious idea and years of subsequent work, Frances Arnold turned bioengineering upside down. Recognising that nature was “the best bioengineer in history,” she figured out how to let evolution be her partner in the lab. She pioneered the use of directed evolution to design new enzymes, with applications as broad as they are essential, from pharmaceuticals to renewable fuels.