1997
Press release
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NOBELFÖRSAMLINGEN KAROLINSKA INSTITUTET THE NOBEL ASSEMBLY AT THE KAROLINSKA INSTITUTE 6 October 1997 has today decided to award the Nobel Prize in Physiology or Medicine for 1997 to Stanley B. Prusiner for his discovery of “Prions – a new biological principle of infection”. Summary The 1997 Nobel Prize in Physiology or Medicine is awarded to…
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Animation
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2. When a cow is fed with offals derived from a PrPSc-infected sheep, prions are somehow taken up from the gut and transported to the brain. The details of this process are not yet known, but one likely scenario is that PrPSc enters a nerve ending (synapse) from where it is transported along the nerve…
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med-ani1
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This animation gives a very simplified view of how prions cause fatal neurodegenerative diseases of the brain in man and animals next step 1. The prion protein, PrP, is a normal constituent of many cell types in the body, notably nerve cells (neurons) in the brain. The name prion (pronounced pree-on) is derived from”proteinaceous infectious…
moreAward ceremony speech
Award ceremony speech
Presentation Speech by Professor Bertil Andersson of the , December 10, 1997. Translation of the Swedish text. Your Majesties, Your Royal Highnesses, Ladies and Gentlemen, Life requires energy. Our muscles require energy when we move. We need energy to think. Energy input is required for the production of new biological molecules. This year’s three Nobel…
moreJohn E. Walker – Biographical
Biographical
I was born in Halifax, Yorkshire on January 7th, 1941 to Thomas Ernest Walker and Elsie Walker (née Lawton). My father was a stone mason, and a talented amateur pianist and vocalist. I was brought up with my two younger sisters, Judith and Jennifer, in a rural environment overlooking the Calder valley near Elland, and…
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“The Binding Change Mechanism”
Paul D. Boyer and John E. Walker have shown how the enzyme ATP synthase makes ATP. ATP synthase is found in chloroplast and mitochondrial membranes and in the cytoplasmic membrane of bacteria. A difference in hydrogen ion concentration across the membrane drives the enzyme to synthesise ATP. Using chemical methods Paul Boyer proposed…
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