Women who changed science celebrates and explores the contributions, careers and lives of 19 women who have been awarded Nobel Prizes for their scientific achievements. Explore their stories by clicking the images below. The compilation includes Nobel Prizes up to 2018.
With one ingenious idea and years of subsequent work, Frances Arnold turned bioengineering upside down. Recognising that nature was “the best bioengineer in history,” she figured out how to let evolution be her partner in the lab. She pioneered the use of directed evolution to design new enzymes, with applications as broad as they are essential, from pharmaceuticals to renewable fuels.
Elizabeth Blackburn has evolved from a self-described “lab rat” to an explorer in the realms of health and public policy. She discovered the molecular structure of telomeres and co-discovered the enzyme telomerase, essential pieces in the puzzle of cellular division and DNA replication.
Linda Buck was fascinated by one seemingly simple question: how does our sense of smell work? Once she started to look for the answer, she didn’t let it go. She followed the olfactory process step by step to the very heart of what makes us human: our perceptions, preferences and memories.
Françoise Barré-Sinoussi dedicated her career as a scientist and as an activist to halting the spread of AIDS. Her discovery of HIV led to blood tests that could detect the infection, and ultimately to anti retroviral medications that have turned AIDS from a death sentence to a manageable chronic disease. For the people around the world who don’t have access to AIDS drugs, Barré-Sinoussi has been a tireless advocate.
Marie Curie is still the only individual to receive the prize in two different science categories. Her relentless resolve and insatiable curiosity made her an icon in the world of modern science. Indefatigable despite a career of physically demanding and ultimately fatal work, she discovered polonium and radium, championed the use of radiation in medicine and fundamentally changed our understanding of radioactivity.
Gerty Cori uncovered the process of cellular energy storage and release, answering one of the most fundamental questions about how the human body works. In so doing, she and her husband and lifelong research partner, Carl, transformed the study of biology, proving that the clarity of molecular chemistry could and should be applied to the opaque mechanisms of biology.
For most of her career, Maria Goeppert Mayer worked “just for the fun of doing physics,” without pay or status or a tenured position. She was 58 before she became a full professor. And yet she made major contributions to the growing understanding of nuclear physics, including the revelatory nuclear shell model.
With the drugs that she created, Gertrude Elion fulfilled her life’s mission: to alleviate human suffering. Beyond the individual drugs she discovered, she pioneered a new, more scientific approach to drug development that forever altered – and accelerated – medical research.
The radiochemist Irène Joliot-Curie was a battlefield radiologist, activist, politician, and daughter of two of the most famous scientists in the world: Marie and Pierre Curie. Along with her husband, Frédéric, she discovered the first-ever artificially created radioactive atoms, paving the way for innumerable medical advances, especially in the fight against cancer.
Carol Greider achieved success in molecular biology in the same way she overcame dyslexia as a child: with persistence and creativity. She discovered telomerase, an enzyme that is key to the ageing process and the growth of cancer cells, and has major implications for medical research.
“Captured for life by chemistry and by crystals,” as she described it, Dorothy Hodgkin turned a childhood interest in crystals into the ground-breaking use of X-ray crystallography to “see” the molecules of penicillin, vitamin B12 and insulin. Her work not only allowed researchers to better understand and manufacture life-saving substances, it also made crystallography an indispensable scientific tool.
Rita Levi-Montalcini began her scientific career in danger, as a Jew in Fascist Italy. She ended it in triumph, as the neuroembryologist who co-discovered nerve growth factor, a prominent figure in Italian politics, and an active researcher and mentor until her death at the age of 103.
Donna Strickland thinks lasers are cool. With enthusiasm for the field and “very, very hard” work, she found a way to create high-intensity laser pulses. This technique, chirped pulse amplification or CPA, was described in Strickland’s very first scientific paper, and it led to her 2018 Nobel Prize in Physics. More important, it began a long career in which, as she has put it, “I get to play with high-intensity lasers.”
Neuroscientist May-Britt Moser persisted in a decades-long quest to understand how the brain worked at a cellular level. She persevered through a series of challenges – from a reluctant PhD advisor to the birth of two daughters – with a stubborn sense of purpose. Together with her then-husband, Edvard, she learned how the brain perceives where the body is positioned and discovered the cellular basis of cognitive function.
Christiane Nüsslein-Volhard approaches biology with the rigour of a scientist and the sensibility of an artist. She helped solve one of biology’s great mysteries: how the genes in a fertilised egg form an embryo. She pursues her love of music and cooking in her spare time, but even her work itself – the quest to understand nature – is, she believes, a creative act.
Throughout her career, Barbara McClintock studied the cytogenetics of maize, making discoveries so far beyond the understanding of the time that other scientists essentially ignored her work for more than a decade. But she persisted, trusting herself and the evidence under her microscope.
Rosalyn Yalow became a physicist at a time when being a woman was a serious impediment to success. But succeed she did. With her research partner Solomon Berson, she made a transformative contribution to medical research: radioimmunoassay, a method for measuring concentrations of substances in the blood.
Tu Youyou turned to Chinese medical texts from the Zhou, Qing, and Han Dynasties to find a traditional cure for malaria, ultimately extracting a compound – artemisinin – that has saved millions of lives. When she isolated the ingredient she believed would work, she volunteered to be the first human subject. She is the first mainland Chinese scientist to have received a Nobel Prize in a scientific category, and she did so without a doctorate, a medical degree, or training abroad.
Ever since she was a girl, Ada Yonath has set herself seemingly impossible goals, and then figured out how to reach them, step by step. As a young scientist she took on a challenge that others considered hopeless – mapping the structure of the ribosome – and persevered for decades until she succeeded. Her determination and ingenuity allowed researchers to see and understand the complex and crucial molecule. And since the ribosome is a major bacterial target for antibiotics, her work has led to new antibiotics and a better understanding of antibiotic resistance.
