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Nobel Prizes and Laureates

Nobel Prizes and Laureates

The Nobel Prize in Chemistry 2003
Peter Agre, Roderick MacKinnon

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Roderick MacKinnon - Facts

Roderick MacKinnon

Roderick MacKinnon

Born: 19 February 1956, Burlington, MA, USA

Affiliation at the time of the award: Rockefeller University, New York, NY, USA, Howard Hughes Medical Institute

Prize motivation: "for structural and mechanistic studies of ion channels"

Field: biochemistry, structural chemistry

Prize share: 1/2

Life

Roderick MacKinnon was born in Burlington, Massachusetts. As an adult, he studied not far from Massachusetts' capital, Boston. He first studied biochemistry at Brandeis University and then earned a medical degree from Tufts University in 1982. After a few years working as a doctor, MacKinnon returned to Brandeis University as a researcher at age 30. He later moved to Harvard University in 1989 and then to Rockefeller University, New York, in 1996, where he conducted the research that led to his Nobel Prize. Roderick MacKinnon is married to Alice Lee, an organic chemist.

Work

One of life's most fundamental processes is the transportation of charged atoms (ions) through the outer walls of the cells that make up living organisms. Known as ion channels, these pathways are vitally important to signal transfers in nerves and muscles, although just how they are constructed long remained a mystery. In 1998, using x-ray crystallography (that is, mapping molecule structures using the diffraction patterns that occur when x-rays pass through crystals), Roderick MacKinnon succeeded in demonstrating what a potassium ion channel looks like.

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