Fritz Albert Lipmann
Born: 12 June 1899, Koenigsberg (now Kaliningrad), Germany (now Russia)
Died: 24 July 1986, Poughkeepsie, NY, USA
Affiliation at the time of the award: Harvard Medical School, Boston, MA, USA, Massachusetts General Hospital, Boston, MA, USA
Prize motivation: "for his discovery of co-enzyme A and its importance for intermediary metabolism"
Field: biochemistry, cell physiology, metabolism
Prize share: 1/2
In 1937 Hans Krebs presented a complete picture of an important part of metabolism - the citric acid cycle. In this process, which has several steps, nutrients are converted to other molecules with a large amount of chemical energy. An important piece of the process was still missing - a substance that along with a protein forms an enzyme that facilitates an important step. In 1946 the substance was discovered by Fritz Lipmann, who described its role plays and gave it the name coenzyme A.
"for his discoveries in connection with the biological combustion processes, with special reference to vitamin C and the catalysis of fumaric acid"
"for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism"
"for his discovery of the nature and mode of action of the respiratory enzyme"