1998
Furchgott’s sandwich
Robert F Furchgott showed that acetylcholine-induced relaxation of blood vessels was dependent on the endothelium. His “sandwich” experiment set the stage for future scientific development. He used two different pieces of the aorta; one had the endothelial layer intact, in the other it had been removed.
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Murad’s enzyme activation
Ferid Murad knew that nitroglycerine caused relaxation of smooth muscle cells. The enzyme, guanylyl cyclase, was activated and increased cyclic GMP, causing relaxation of the muscle. Did nitroglycerin act via release of nitric oxide, NO? He bubbled NO-gas through tissue containing the enzyme; cyclic GMP increased! A new mode of drug action had been discovered!…
morePress release
Press release
English 13 October 1998 has awarded the 1998 Nobel Prize in Chemistry to Professor Walter Kohn, University of California at Santa Barbara, USA and, Professor John A. Pople, Northwestern University, Evanston, Illinois, USA (British citizen). The Laureates have each made pioneering contributions in developing methods that can be used for theoretical studies of the properties…
moreAward ceremony speech
Award ceremony speech
Presentation Speech by Professor Björn Roos of the , December 10, 1998. Translation of the Swedish text. Professor Björn Roos delivering the Presentation Speech for the 1998 Nobel Prize in Chemistry at the Stockholm Concert Hall. Photo: Hans Mehlin, Nobelprize.org Your Majesties, Your Royal Highness, Ladies and Gentlemen, Man is fantastic. Through his studies…
morePressmeddelande: Nobelpriset i kemi 1998
Press release
Swedish 13 oktober 1998 har utdelat 1998 års Nobelpris i kemi inom området kvantkemi till Walter Kohn, University of California at Santa Barbara, USA och John A. Pople, Northwestern University, Evanston, Illinois, USA (brittisk medborgare). Pristagarna har var för sig gjort banbrytande insatser för att utveckla metoder som kan användas för att teoretiskt studera molekylers…
moreWave-function methods
John A. Pople has developed computational methods in chemistry. These are based on different descriptions of the wave function in the Schrödinger equation. He has created a theoretical model chemistry in which a series of increasingly refined approximations systematically approaches the exact solution to the quantum-mechanical equations. In this way it has become possible…
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