The Laureates

Peter Agre, Johns Hopkins University School of Medicine

Roderick MacKinnon, The Rockefeller University

Animations

Water channels

Original papers

“Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein”. Preston, G.M., Carroll, T.P., Guggino, W.B., and Agre, P. (1992). Science 256, 385-387.

“Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein”. Zeidel, M.L., Ambudkar, S.V., Smith, B.L., and Agre, P. (1992). Biochemistry 31, 7436-7440.

“The structure of the potassium channel: Molecular basis of K⁺ conduction and selectivity”. D.A. Doyle, J. Morais Cabral, R.A. Pfuetzner, A. Quo, J.M. Gulbis, S.L. Cohen, B.T. Chait and R. MacKinnon. Science 280 (1998) 69-77.

“Energetic optimization of ion conduction rate by the K⁺ selectivity filter”. J.H. Morais-Cabral, Y. Zhou and R. MacKinnon. Nature 414 (2001) 37-47.

“Crystal structure and mechanism of a calcium-gated potassium channel”, Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., and MacKinnon, R. (2002). Nature 417, 515-522.

Other articles

“Aquaporin Water Channels: Molecular Mechanisms for Human Diseases”. P. Agre and D. Kozono, FEBS Letters, papers in press, October 2003.

“Aquaporin Water Channels: Atomic structure and molecular dynamics meet clinical medicine”. D. Kozono, M. Yasui, L.S. King and P. Agre. The Journal of Clinical Investigation 109 (2002) 1395-1399.

“Potassium Channels”. R. MacKinnon FEBS Letters, papers in press, October 2003.