Gregg L. Semenza

Facts

Gregg L. Semenza

© Nobel Media. Photo: A. Mahmoud

Gregg L. Semenza
The Nobel Prize in Physiology or Medicine 2019

Born: 12 July 1956, New York, NY, USA

Affiliation at the time of the award: Johns Hopkins University, Baltimore, MD, USA

Prize motivation: "for their discoveries of how cells sense and adapt to oxygen availability."

Prize share: 1/3

Life

Harvard University, he pursued doctoral studies at the University of Pennsylvania in Philadelphia, receiving his doctorate there in 1984. After completing his pediatric training, he began working at Johns Hopkins University in Baltimore, Maryland, where he is still active.

Work

Animals need oxygen for the conversion of food into useful energy. The importance of oxygen has been understood for centuries, but how cells adapt to changes in levels of oxygen has long been unknown. William Kaelin, Peter Ratcliffe, and Gregg Semenza discovered how cells can sense and adapt to changing oxygen availability. During the 1990s they identified a molecular machinery that regulates the activity of genes in response to varying levels of oxygen. The discoveries may lead to new treatments of anemia, cancer and many other diseases.

To cite this section
MLA style: Gregg L. Semenza – Facts – 2019. NobelPrize.org. Nobel Media AB 2020. Thu. 22 Oct 2020. <https://www.nobelprize.org/prizes/medicine/2019/semenza/facts/>

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