Nobel Prize

The Laureates Aaron Ciechanover, Technion (Israel Institute of Technology) Avram Hershko, Technion (Israel Institute of Technology)   Original Papers Ciechanover, A., Hod, Y., and Hershko, A. (1978) “A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes”. Biochem. Biophys. Res. Commun. 81, pp. 1100-1105. Hershko, A., Ciechanover, A., and Rose, I.A. (1979) “Resolution of…

Swedish Presentationstal av Professor Lars Thelander, ledamot av , i Stockholms Konserthus 10 december 2004. Professor Lars Thelander presenterar Nobelpriset i kemi 2004 i Stockholms Konserthus. Eders Majestäter, Eders Kungliga Högheter, mina damer och herrar, Årets Nobelpristagare i kemi belönas för sin upptäckt av livets egen dödsmärkning och för att samtidigt ha löst…

Swedish 6 oktober 2004 har beslutat utdela Nobelpriset i kemi år 2004 “för upptäckten av ubiquitinmedierad proteinnedbrytning” gemensamt till Aaron Ciechanover Technion – Israel Institute of Technology, Haifa, Israel, Avram Hershko Technion – Israel Institute of Technology, Haifa, Israel och Irwin Rose University of California, Irvine, USA. Dödsmärkning av proteiner Proteiner bygger upp allt levande:…

  The Nobel Prize in Chemistry 2004         Credits     Editors: Lars Thelander and Bengt Nordén, Members of the Nobel Committee for Chemistry. Eva Krutmeijer, Malin Lindgren and Anna Lindquist, The Royal Swedish Academy of Sciences. Layout and Illustrations: Kjell Lundin Printing: Katarinatryck AB, 2004 © The Royal Swedish Academy of…

  The Nobel Prize in Chemistry 2004             Proteins are life’s building-blocks In the tiniest intestinal bacteria, in roses and toadstools, in mice and men – in all living cells – proteins answer for both form and function. Naturally, research into proteins is therefore of the greatest interest, particularly for…

  The Nobel Prize in Chemistry 2004             Prevents self-polination Did you know that roses are bisexual? Most plants are like this – they’re hermaphrodites. With such an arrangement, one wonders what prevents plants from fertilising themselves. In fact, ubiquitin-mediated protein breakdown is involved: the plant recognises and rejects its…

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  The Nobel Prize in Chemistry 2004             Ubiquitin This is what the actual label looks like. It consists of a short polypeptide chain, a small protein that is so common in the cells of different organisms that it was early named ubiquitin, from the Latin ubique, ‘everywhere’. This protein…

  The Nobel Prize in Chemistry 2004           The most common reason for miscarriage is an error when the mother’s and the father’s chromosomes are to be separated in the formation of sex cells. Ubiquitin-marking plays an important role here. The picture shows a calf embryo.   How are sex cells…

  The Nobel Prize in Chemistry 2004             What proteins are marked? Surprisingly many of the proteins created in the cell are faulty from the start. They must be broken down and rebuilt since they can damage the organism. But perhaps the most important reason for a cell to get…