An important step in biochemical research was taken in 1980 when Hartmut Michel managed to crystallize a membrane protein (bacteriorhodopsin) after having solubilized the lipid bilayer of the membrane with a detergent. Detergents, which are structurally similar to membrane lipids, form micelles in water. They bind to membrane proteins with their fatty, hydrophobic tails creating an environment which mimics that in the membrane. Michel found a method to crystallize such protein-detergent complexes. Two years later a definitive breakthrough took place as Michel succeeded in crystallizing the reaction center from the photosynthetic bacterium Rhodopseudomonas viridis.
Their work and discoveries range from cancer therapy and laser physics to developing proteins that can solve humankind’s chemical problems. The work of the 2018 Nobel Laureates also included combating war crimes, as well as integrating innovation and climate with economic growth. Find out more.