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It has long been clear how proteins are built up in the cell. But the opposite, how they are broken down, was long thought to be less exciting to study. This year’s Nobel Laureates, Aaron Ciechanover, Avram Hershko and Irwin Rose, went against the stream and, at the beginning of the 1980s, discovered one of the cell’s most important control mechanisms, controlled protein degradation.
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Irwin Rose
College of Medicine, University of California, Irvine, USA |
Avram Hershko Rappaport Institute, Technion – Israel Institute of Technology Haifa, Israel |
Aaron Ciechanover Rappaport Institute, Technion – Israel Institute of Technology Haifa, Israel |
The discovery was made at the beginning of the 1980s at the Fox Chase Cancer Center in Philadelphia, USA, jointly by the three scientists.
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