Alfred G. Gilman

Facts

Alfred G. Gilman

Photo from the Nobel Foundation archive.

Alfred G. Gilman
The Nobel Prize in Physiology or Medicine 1994

Born: 1 July 1941, New Haven, CT, USA

Died: 23 December 2015, Dallas, TX, USA

Affiliation at the time of the award: University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA

Prize motivation: “for their discovery of G-proteins and the role of these proteins in signal transduction in cells”

Prize share: 1/2

Work

In order for an organism to function, signals are conveyed within and between the body’s various organs and cells through electrical currents and special molecules. Alfred Gilman and Martin Rodbell showed how the signal transfer through the cell wall happens. Around 1970 Rodbell demonstrated that the signal transfer occurs in three steps—reception, transfer and reinforcement—and that guanosine triphosphate is a driving force in the transfer. In 1980 Gilman discovered that molecules involved in the transfer are a type of protein that reacts with GTP—G proteins.

To cite this section
MLA style: Alfred G. Gilman – Facts. NobelPrize.org. Nobel Prize Outreach AB 2024. Tue. 23 Jul 2024. <https://www.nobelprize.org/prizes/medicine/1994/gilman/facts/>

Back to top Back To Top Takes users back to the top of the page

Nobel Prizes and laureates

Eleven laureates were awarded a Nobel Prize in 2023, for achievements that have conferred the greatest benefit to humankind. Their work and discoveries range from effective mRNA vaccines and attosecond physics to fighting against the oppression of women.

See them all presented here.
Illustration

Explore prizes and laureates

Look for popular awards and laureates in different fields, and discover the history of the Nobel Prize.