5. In neurons infected with the prion protein, more and more PrPSc will gradually be produced forming larger fibrillar aggregates. When a critical level of PrPSc has accumulated, the neurons die, resulting in large vacuoles. The affected brain regions become sponge-like in appearance, hence the name spongiform encephalopathies, to describe all prion diseases.



To cite this section
MLA style: Animation. Nobel Media AB 2020. Wed. 15 Jul 2020. <>

Back to top Back To Top Takes users back to the top of the page

Explore prizes and laureates

Look for popular awards and laureates in different fields, and discover the history of the Nobel Prize.