5. In neurons infected with the prion protein, more and more PrPSc will gradually be produced forming larger fibrillar aggregates. When a critical level of PrPSc has accumulated, the neurons die, resulting in large vacuoles. The affected brain regions become sponge-like in appearance, hence the name spongiform encephalopathies, to describe all prion diseases.
Their work and discoveries range from cancer therapy and laser physics to developing proteins that can solve humankind’s chemical problems. The work of the 2018 Nobel Laureates also included combating war crimes, as well as integrating innovation and climate with economic growth. Find out more.