Animation

5. In neurons infected with the prion protein, more and more PrPSc will gradually be produced forming larger fibrillar aggregates. When a critical level of PrPSc has accumulated, the neurons die, resulting in large vacuoles. The affected brain regions become sponge-like in appearance, hence the name spongiform encephalopathies, to describe all prion diseases.

 

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MLA style: Animation. NobelPrize.org. Nobel Media AB 2018. Tue. 13 Nov 2018. <https://www.nobelprize.org/prizes/medicine/1997/7803-animation-1997-3/>

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